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Chitosan and Chitosan-Based Biomaterials
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Chitosan and Chitosan-Based Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 August 2018) | Viewed by 6647

Special Issue Editor

Prof. Sundararajan V. Madihally

E-Mail Website
Guest Editor
School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, OK 74078, USA
Interests: 3D cell culturing; bioreactors for tissue regeneration; composite tissue regeneration; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitosan has been explored in regenerative medicine in various forms. It has been processed into structures using variety of techniques, such as freeze drying, electrospinning, and 3D printing. Chitosan is combined with other biomaterials for soft tissue applications or with ceramic crystals in bone regeneration. Additionally, there has been significant effort in the development of thermosensitive hydrogels. Mechanical characteristics and degradation characteristics of chitosan and their combinations are also evaluated in these structures. This Special Issue focusses on recent advances in these areas. Both original research articles or comprehensive reviews are welcome.

Prof. Sundararajan V. Madihally
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • combination
  • scaffolds
  • mechanical properties
  • gelation
  • tissue regeneration

Published Papers (1 paper)

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Research

15 pages, 6059 KiB  
Article
Development and Evaluation of an Injectable Chitosan/β-Glycerophosphate Paste as a Local Antibiotic Delivery System for Trauma Care
by Logan Boles, Christopher Alexander, Leslie Pace, Warren Haggard, Joel Bumgardner and Jessica Jennings
J. Funct. Biomater. 2018, 9(4), 56; https://doi.org/10.3390/jfb9040056 - 12 Oct 2018
Cited by 11 | Viewed by 6370
Abstract
Complex open musculoskeletal wounds are a leading cause of morbidity worldwide, partially due to a high risk of bacterial contamination. Local delivery systems may be used as adjunctive therapies to prevent infection, but they may be nondegradable, possess inadequate wound coverage, or migrate [...] Read more.
Complex open musculoskeletal wounds are a leading cause of morbidity worldwide, partially due to a high risk of bacterial contamination. Local delivery systems may be used as adjunctive therapies to prevent infection, but they may be nondegradable, possess inadequate wound coverage, or migrate from the wound site. To address this issue, a thermo-responsive, injectable chitosan paste was fabricated by incorporating beta-glycerophosphate. The efficacy of thermo-paste as an adjunctive infection prevention tool was evaluated in terms of cytocompatibility, degradation, antibacterial, injectability, and inflammation properties. In vitro studies demonstrated thermo-paste may be loaded with amikacin and vancomycin and release inhibitory levels for at least 3 days. Further, approximately 60% of thermo-paste was enzymatically degraded within 7 days in vitro. The viability of cells exposed to thermo-paste exceeded ISO 10993-5 standards with approximately 73% relative viability of a control chitosan sponge. The ejection force of thermo-paste, approximately 20 N, was lower than previously studied paste formulations and within relevant clinical ejection force ranges. An in vivo murine biocompatibility study demonstrated that thermo-paste induced minimal inflammation after implantation for 7 days, similar to previously developed chitosan pastes. Results from these preliminary preclinical studies indicate that thermo-paste shows promise for further development as an antibiotic delivery system for infection prevention. Full article
(This article belongs to the Special Issue Chitosan and Chitosan-Based Biomaterials)
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