Drug Biotransformation by Marine Animals
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 April 2019) | Viewed by 178
Special Issue Editor
Interests: Drug (xenobiotic) biotransformation in humans and different animal species, including aquatic animals. Of particular interest are pathways that influence xenobiotic toxicity and interactions of xenobiotics with biotransformation of endogenous molecules such as steroids.
Special Issue Information
Dear Colleagues,
Marine organisms are known to produce a variety of small organic molecules with drug-like properties, some of which have been shown to have therapeutic potential for treatment of human diseases. Coastal areas are often the recipients of effluents which contain human and animal pharmaceuticals as well as personal care products. In both scenarios, marine fish, shellfish and other organisms will be exposed to drugs and other xenobiotics. Variables in the environment that can affect uptake, biotransformation and elimination of xenobiotics by marine animals include the properties of the xenobiotic, the water temperature, local environment and the species of animal. Understanding the biotransformation and disposition of drugs in marine animals is important in predicting how readily drugs could be eliminated from different animals, as well as in assessing species differences in pathways of drug biotransformation.
This Special Issue is open to contributions presenting studies on the biotransformation of drugs and drug-like xenobiotics in marine animals. Papers reporting on the following are welcome: i) in vivo studies of the uptake and elimination of drugs by marine organisms; ii) in vitro studies presenting the properties and enzymology of particular metabolizing pathways such as cytochrome P450 monooxygenases; iii) novel drug-metabolizing pathways in marine animals; and iv) the regulation of drug-metabolizing enzymes by temperature, presence of pollutant chemicals or changes associated with reproduction and development.
Prof. Margaret O. James
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Drug biotransformation
- Marine animals
- Environmental influences on drug-metabolizing enzymes
- Drug elimination
