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Marine Drugs
Special Issues
Marine-derived Bioactive Peptides and Lipids Applied in Non-communicable Diseases
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Marine-derived Bioactive Peptides and Lipids Applied in Non-communicable Diseases

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 November 2018) | Viewed by 17500

Special Issue Editor

Dr. Constantina Nasopoulou

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Guest Editor
Department of Food Science and Nutrition, School of the Environment, University of the Aegean, Metropolite Ioakeim 2, 81400 Myrina, Lemnos, Greece
Interests: marine functional food products; food biotechnology; antithrombotic; antiatherogenic properties of marine bioactive lipid micro constituents; inflammation; biological assays; gas chromatrograpy-mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-communicable diseases, such as cardiovascular diseases, different types of cancer, respiratory diseases and diabetes, are the leading cause of death globally. Marine species are valuable source of bioactive constituents, such as peptides, proteins and lipids. Marine-derived biopeptides—due to their structural properties and their amino acids composition and sequences - exhibit various biological activities such as anti-atherosclerotic, anti-hypertensive, anti-cancer, anti-diabetic, anti-oxidative, anti-obesity activity, etc., preventing non-communicable diseases. Additionally, marine-derived bioactive lipids such as marine phosholipids have high content of the long-chain polyunsaturated omega-3 fatty acids EPA and DHA and exhibit numerous biological properties against atherosclerosis, thrombosis and inflammation. Therefore, the purpose of the current Special Issue is to publish novel ideas related to the therapeutic potential of marine-derived bioactive peptides and lipids in the treatment or prevention of non-communicable diseases, underlining the possible use of the aforementioned bioactive constituents as functional food ingredients, nutraceuticals or pharmaceuticals.

Dr. Constantina Nasopoulou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Marine species
  • Marine-derived bioactive peptides
  • Marine-derived bioactive phospholipids
  • Non-communicable diseases
  • Nutraceuticals

Published Papers (3 papers)

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Research

23 pages, 3381 KiB  
Article
In Vitro Antithrombotic Properties of Salmon (Salmo salar) Phospholipids in a Novel Food-Grade Extract
by Alexandros Tsoupras, Ronan Lordan, Katie Shiels, Sushanta Kumar Saha, Constantina Nasopoulou and Ioannis Zabetakis
Mar. Drugs 2019, 17(1), 62; https://doi.org/10.3390/md17010062 - 18 Jan 2019
Cited by 35 | Viewed by 6107
Abstract
Marine and salmon polar lipids (PLs) extracted by conventional extractions with non-food-grade solvents (CE-salmon-PLs) possess antithrombotic bioactivities against platelet-activating factor (PAF) and thrombin. Similar effects of food-grade-extracted (FGE) marine PLs have not yet been reported. In this study, food-grade solvents were used to [...] Read more.
Marine and salmon polar lipids (PLs) extracted by conventional extractions with non-food-grade solvents (CE-salmon-PLs) possess antithrombotic bioactivities against platelet-activating factor (PAF) and thrombin. Similar effects of food-grade-extracted (FGE) marine PLs have not yet been reported. In this study, food-grade solvents were used to extract PLs from Irish organic farmed salmon (Salmo salar) fillets (FGE-salmon-PLs), while their antithrombotic bioactivities were assessed in human platelets induced by platelet aggregation agonists (PAF/thrombin). FGE-salmon-PLs were further separated by thin layer chromatography (TLC) into lipid subclasses, and the antithrombotic bioactivities of each subclass were also assessed. LC-MS was utilized to elucidate the structure-activity relationships. FGE-salmon-PLs strongly inhibited PAF-induced platelet aggregation, while their relevant anti-thrombin effects were at least three times more potent than the previously reported activities of CE-salmon-PLs. TLC-derived lipid fractions corresponding to phosphatidylcholines (PC) and phosphatidylethanolamines (PE) were the most bioactive lipid subclasses obtained, especially against thrombin. Their LC-MS analysis elucidated that they are diacyl- or alkyl-acyl- PC and PE moieties baring ω3 polyunsaturated fatty acids (PUFA) at their sn-2 position, such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Our results concerning the potent antithrombotic effects of FGE-salmon-PLs against both PAF and thrombin pathways strongly suggest that such food-grade extracts are putative candidates for the development of novel cardioprotective supplements and nutraceuticals. Full article
(This article belongs to the Special Issue Marine-derived Bioactive Peptides and Lipids Applied in Non-communicable Diseases)
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16 pages, 3828 KiB  
Article
High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets
by Yunhai Yi, Yunyun Lv, Lijun Zhang, Jian Yang and Qiong Shi
Mar. Drugs 2018, 16(10), 365; https://doi.org/10.3390/md16100365 - 02 Oct 2018
Cited by 12 | Viewed by 3678
Abstract
Antihypertensive peptides (AHTPs) are a group of small peptides with the main role to block key enzymes or receptors in the angiotensin genesis pathway. A great number of AHTPs have been isolated or digested from natural food resources; however, comprehensive studies on comparisons [...] Read more.
Antihypertensive peptides (AHTPs) are a group of small peptides with the main role to block key enzymes or receptors in the angiotensin genesis pathway. A great number of AHTPs have been isolated or digested from natural food resources; however, comprehensive studies on comparisons of AHTPs in various species from the perspective of big data are rare. Here, we established a simplified local AHTP database, and performed in situ mapping for high throughput identification of AHTPs with high antihypertensive activity from high-quality whole proteome datasets of 18 fish species. In the 35 identified AHTPs with reported high activity, we observed that Gly-Leu-Pro, Leu-Pro-Gly, and Val-Ser-Val are the major components of fish proteins, and AHTP hit numbers in various species demonstrated a similar distributing pattern. Interestingly, Atlantic salmon (Salmo salar) is in possession of far more abundant AHTPs compared with other fish species. In addition, collagen subunit protein is the largest group with more matching AHTPs. Further exploration of two collagen subunits (col4a5 and col8a1) in more fish species suggested that the hit pattern of these conserved proteins among teleost is almost the same, and their phylogeny is consistent with the evolution of these fish species. In summary, our present study provides basic information for the relationship of AHTPs with fish proteins, which sheds light on rapid discovery of marine drugs or food additives from fish protein hydrolysates to alleviate hypertension. Full article
(This article belongs to the Special Issue Marine-derived Bioactive Peptides and Lipids Applied in Non-communicable Diseases)
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19 pages, 3602 KiB  
Article
Structural Elucidation of Irish Organic Farmed Salmon (Salmo salar) Polar Lipids with Antithrombotic Activities
by Alexandros Tsoupras, Ronan Lordan, Martina Demuru, Katie Shiels, Sushanta Kumar Saha, Constantina Nasopoulou and Ioannis Zabetakis
Mar. Drugs 2018, 16(6), 176; https://doi.org/10.3390/md16060176 - 23 May 2018
Cited by 42 | Viewed by 7129
Abstract
While several marine polar lipids (PL) have exhibited cardioprotective properties through their effects on the platelet-activating factor (PAF) pathways, salmon PL have not been tested so far. In this study, the antithrombotic activities of salmon PL were assessed in human platelets and the [...] Read more.
While several marine polar lipids (PL) have exhibited cardioprotective properties through their effects on the platelet-activating factor (PAF) pathways, salmon PL have not been tested so far. In this study, the antithrombotic activities of salmon PL were assessed in human platelets and the structural characterisation of bioactive salmon PL was performed by GC-MS and LC-MS analyses. PL from fillets of Irish organic farmed salmon (Salmo salar) were extracted and separated into several lipid subclasses by thin-layer chromatography (TLC), while their fatty acid profile was fully characterised by GC-MS. Salmon total lipids (TL), total neutral lipids (TNL), total polar lipids (TPL), and each PL subclass obtained by TLC were further assessed for their in vitro effects towards PAF-induced and thrombin-induced platelet aggregation in human platelets. Salmon PL exhibited antithrombotic effects on human platelet aggregation, mostly through their strong inhibitory effects against the PAF pathway with IC50 values comparable to other marine PL, but with lower effects towards the thrombin pathway. PL fractions corresponding to phosphatidylcholine and phosphatidylethanolamine derivatives exhibited the most potent anti-PAF effects, while LC-MS analysis putatively elucidated their structure/function relationship. Several diacyl-PC/PE and alkyl-acyl-PC/PE species containing mostly docosahexaenoic acid at their sn-2 glycerol-backbone may be responsible for the bioactivity. The data presented suggests that salmon contains PL with strong antithrombotic bioactivities. Full article
(This article belongs to the Special Issue Marine-derived Bioactive Peptides and Lipids Applied in Non-communicable Diseases)
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