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Special Issue "Connecting Marine Microbial Natural Products to Biosynthetic Pathways"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 May 2017)

Special Issue Editors

Guest Editor
Prof. Dr. Marcy J. Balunas

Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Connecticut, 69 N. Eagleville Rd. Unit 3092, Storrs, CT 06231, USA
Website | E-Mail
Phone: +1-860-486-3051
Interests: marine microbes; natural products chemistry; host-microbe symbioses; antimicrobial and anticancer drug discovery; chemical ecology
Guest Editor
Prof. Dr. Amy L. Lane

Department of Chemistry, University of North Florida, 1 UNF Dr., Jacksonville, FL 32224, USA
Website | E-Mail
Phone: +1-904-620-2315
Fax: +1-904-620-3535
Interests: marine natural products; biosynthesis; chemical ecology; actinomycetes; polyketides; indole alkaloids; nonribosomal peptides

Special Issue Information

Dear Colleagues,

The recent surge in genome sequencing has illuminated the genetically encoded capabilities of microorganisms to assemble natural products. These efforts have shown that marine microorganisms offer immense potential as producers of biologically active, structurally intriguing molecules underpinned by equally fascinating biosynthetic pathways. The merger of natural product structures with biosynthetic knowledge provides opportunities for advancement of fields including chemical ecology and medicinal chemistry.

This Special Issue focuses on linking marine microbial natural product structures with their biosynthetic origins. Articles will highlight how the merger of these research areas facilitates advancements in fundamental understanding of marine natural products, as well as applications of this knowledge in medicine, agriculture, and other fields.

Prof. Dr. Marcy J. Balunas
Prof. Dr. Amy L. Lane
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine microbial natural products
  • biosynthetic pathways
  • genomics
  • polyketides
  • nonribosomal peptides
  • isoprenes/terpenes
  • structure elucidation
  • marine cyanobacteria
  • marine bacteria
  • marine fungi

Published Papers (2 papers)

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Research

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Open AccessArticle Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp.
Mar. Drugs 2017, 15(7), 195; doi:10.3390/md15070195
Received: 2 June 2017 / Revised: 13 June 2017 / Accepted: 19 June 2017 / Published: 24 June 2017
PDF Full-text (2188 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Streptomyces sp. GSL-6B was isolated from sediment collected from the Great Salt Lake and investigation of its organic extract led to the isolation of three new linear heptapeptides, bonnevillamides A (1), B (2), and C (3). The
[...] Read more.
Streptomyces sp. GSL-6B was isolated from sediment collected from the Great Salt Lake and investigation of its organic extract led to the isolation of three new linear heptapeptides, bonnevillamides A (1), B (2), and C (3). The bonnevillamides represent a new class of linear peptides featuring unprecedented non-proteinogenic amino acids. All three peptides contain the newly characterized bonnevillic acid moiety (3-(3,5-dichloro-4-methoxyphenyl)-2-hydroxyacrylic acid), as well as a heavily modified proline residue. Moreover, in bonnevillamide A, the terminal proline residue found in bonnevillamides B and C is replaced with 4-methyl-azetidine-2-carboxylic acid methyl ester. The structures of the three heptapeptides were elucidated by NMR, high-resolution electrospray ionization mass spectroscopy (HRESIMS), and LC-MS/MS, and the absolute configuration of all proteinogenic amino acid residues were determined by advanced Marfey’s method. Bonnevillamides A, B and C were evaluated for their effects on zebrafish embryo development. All three heptapeptides were shown to modulate heart growth and cardiac function, with bonnevillamide B having the most pronounced effect. Full article
(This article belongs to the Special Issue Connecting Marine Microbial Natural Products to Biosynthetic Pathways)
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Review

Jump to: Research

Open AccessReview Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations
Mar. Drugs 2017, 15(6), 165; doi:10.3390/md15060165
Received: 28 April 2017 / Revised: 22 May 2017 / Accepted: 31 May 2017 / Published: 6 June 2017
PDF Full-text (2576 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing projects.
[...] Read more.
Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing projects. Here, we focus on limitations of available technology as well as computational and experimental strategies to overcome them. We review the unique challenges and approaches in the study of symbiotic and uncultured systems, as well as those associated with biosynthetic gene cluster (BGC) assembly and product prediction. Finally, to explore sequencing parameters that affect the recovery and contiguity of large and repetitive BGCs assembled de novo, we simulate Illumina and PacBio sequencing of the Salinispora tropica genome focusing on assembly of the salinilactam (slm) BGC. Full article
(This article belongs to the Special Issue Connecting Marine Microbial Natural Products to Biosynthetic Pathways)
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