Special Issue "Marine Anti-inflammatory Agents"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: 31 January 2019
Acute inflammation is a highly-regulated process, and its dysregulation can lead to the development of a chronic inflammatory state, which is believed to play a main role in the pathogenesis of many diseases, including cancer. The molecular mechanisms underlying chronic inflammation are beginning to be elucidated: Reactive oxygen species (ROS) stimulate intracellular signaling pathways and transcription factors, including MAPK and NF-kB. ROS can also activate a multiprotein complex called inflammasome, which regulates the activation of caspase-1 and subsequent maturation of pro-inflammatory cytokines (IL-1β and IL-18). The transcription factor Nrf2 plays a key role in the protection against oxidative stress in numerous inflammatory diseases since it regulates the transcription of antioxidant enzymes. Moreover, the participation of sirtuins, such as SIRT1 and SIRT6 and autophagy in this process is currently being studied.
In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents an excellent source to isolate bioactive compounds from microbes, such as bacteria, cyanobacteria, fungi, algae or small invertebrates, such as sponges, tunicates, bryozoans and mollusks. This Special Issue of Marine Drugs will cover the entire scope of marine agents with anti-inflammatory activities, both in vitro and in vivo, as well as the latest status of clinical development from drug trials. In particular, works that evaluate molecular mechanisms of these compounds are especially encouraged.
Prof. Elena Talero
Dr. Javier Avila
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Marine compounds
- Antioxidant molecules
- Immune response
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Prostaglandins as anti-inflammatory molecules produced in marine environment
Authors: Federica Di Costanzo, Valeria Di Dato, Giovanna Romano
Marine environment is a great source of bioactive compounds that are mainly accumulated in marine organisms. Due to the high biodiversity, research into the use of natural marine products as pharmaceutical agents is still at the beginning and many promising molecules are being studied (1). One example of this molecules are prostaglandins (PGs), a family of lipids mediators, belonging to eicosanoids, with a molecular structure of 20 carbon atoms based on the skeleton of prostanoic acid (2). PGs are typicall of mammals in which they are active in a great variety of physiological and pathological processes. For example, they play a key role in smooth muscle and vaso-tone, inflammation, signalling, haemostasis, and sleep-wake regulation (4). These important molecules are present also in some macroalgae of the genera Gracilaria and Laminaria (3) and in marine invertebrates such as corals, barnacles and tunicates, in which it is reported that they perform roles similar to mammals PGs and are involved also in the control of oogenesis and spermatogenesis, ion transport and defence (4). Recently the PGs pathway has been identified for the first time in unicellular organisms called diatoms. In particular, it has been discovered that in two different strains of the diatom Skeletonema marinoi, the genes of this pathway are differentially expressed (3). In this review we will discuss about the variety of marine organisms that produce prostaglandins and the possible anti-inflammatory role of these molecules in the marine environment.
(1) Biomedical Compounds from Marine organisms
Rajeev Kumar Jha, and Xu Zi-rong
(2) Introduction to the biosynthesis and metabolism of prostaglandins
PRISCILLA J. PIPER
(3) Animal-like prostaglandins in marine microalgae
Valeria Di Dato, Ida Orefice, Alberto Amato, Carolina Fontanarosa, Angela Amoresano, Adele Cutignano, Adrianna Ianora and Giovanna Romano
(4) Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems
Andrew F. Rowley, Claire L. Vogan, Graham W. Taylor and Anthony S. Clare
(5) The Anti-Inflammatory Effects of Prostaglandins
Scher JU, Pillinger MH