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Special Issue "Marine Natural Products and Their Translational Applications in Medicine"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 July 2018

Special Issue Editors

Guest Editor
Dr. Ipek Kurtboke

Senior Lecturer in Environmental Microbiology, School of Science, Education and Engineering, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, Queensland 4558, Australia
Website | E-Mail
Phone: +61 7 5430 2819
Fax: +61 (07) 5430 2881
Interests: microbial diversity; microbial systematics; ecophysiology of microorganisms; functional diversity of microorganisms; microbial ecosystems
Guest Editor
Prof. Dr. Sergey B. Zotchev

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Website | E-Mail
Interests: bioprospecting; endophytes from medicinal plants; bacterial genetics and genomics; bioactive natural products; secondary metabolite biosynthesis; metabolic engineering; synthetic biology

Special Issue Information

Dear Colleagues,

Since the 1960s, marine environments have provided a diverse range of naturally-produced compounds, and, notably, those from marine organisms have been shown to display a variety of biological activities with the potential to be utilized for biotechnological, pharmaceutical, cosmetic and environmental applications. Although there are over 15,000 marine natural products described to date, relatively few of these compounds have made it to clinical trials, let alone received approval by the US Food and Drug Administration (FDA) or the European Agency for the Evaluation of Medicinal Products (EMEA) for marketing. As a result, a translational approach that brings different contributors of biomedical research together might reveal the true potential of marine derived compounds, especially for medicinal applications. The latter is of outmost importance considering the looming crisis of antibiotic resistance and the increasing incidence of cancer. In this Special Issue, the Guest Editors would like to invite marine biodiscovery researchers to contribute a variety of manuscripts that will complement others to provide a comprehensive view of a holistic approach to marine biodiscovery. Manuscripts ranging from search and discovery to marine natural product chemistry to clinical applications of marine natural products are invited.

Dr. Ipek Kurtboke
Prof. Dr. Sergey B. Zotchev
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Marine microorganisms

  • translational applications

  • marine biodiscovery

  • marine biotechnology

  • marine environments

Published Papers (1 paper)

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Open AccessArticle Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.
Mar. Drugs 2018, 16(1), 14; https://doi.org/10.3390/md16010014
Received: 3 November 2017 / Revised: 29 November 2017 / Accepted: 8 December 2017 / Published: 5 January 2018
Cited by 1 | PDF Full-text (2447 KB) | HTML Full-text | XML Full-text | Supplementary Files
A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the
[...] Read more.
A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 15 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 15 had no anti-proliferative effect on human cancer cell lines up to 30 μg/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 μg/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity. Full article

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