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Bioactive Glasses 2019
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Bioactive Glasses 2019

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 18088

Special Issue Editor

Prof. Dr. Gigliola Lusvardi

E-Mail Website
Guest Editor
Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G.Campi 103, 41125 Modena, Italy
Interests: biomaterials; bioceramics; bioglasses; metallic nanoparticles; drug delivery systems; synthesis (traditional, sol-gel and sono-gel); functional biomaterials; surface functionalization; biosensors; characterization (x-ray diffraction, electron microscopy)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive glasses are a group of surface-reactive, glass–ceramic biomaterials; bioactive glasses bond to tissues and are biocompatible. They have a wide range of applications due to their versatile properties, which can be properly designed depending on their composition. A significant improvement in the prevision of glass bioactivity derives from the opportunity to establish relationships between structure and properties by making a combined use of theoretical and experimental techniques. Consequently, bioactive glass science and technology continues to be at the forefront of providing innovative approaches to medicine. The focus of the “Bioactive glasses 2018” Special Issue is to provide and comprehend important topics: Synthesis, design, development and applications of bioglasses. Some interesting topics (among others, and not limited to) are: Bioderived bioglasses with functionalized nanostructures, encapsulation and adsorption of biomolecules in the surface of bioglasses and interactions with the host matrix, molecular dynamics simulation applied at the atomic level regarding the bulk and surface structures of the glasses. With immense pleasure, we invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are welcome.

Prof. Dr. Gigliola Lusvardi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive glasses
  • materials science
  • bioactivity
  • metal nanoparticles
  • glass structure
  • surface functionalization
  • drug delivery systems

Published Papers (5 papers)

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Research

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13 pages, 1757 KiB  
Article
Cell Proliferation to Evaluate Preliminarily the Presence of Enduring Self-Regenerative Antioxidant Activity in Cerium Doped Bioactive Glasses
by Alexandre Anesi, Gianluca Malavasi, Luigi Chiarini, Roberta Salvatori and Gigliola Lusvardi
Materials 2020, 13(10), 2297; https://doi.org/10.3390/ma13102297 - 15 May 2020
Cited by 9 | Viewed by 2035
Abstract
(1) Background: a cell evaluation focused to verify the self-regenerative antioxidant activity is performed on cerium doped bioactive glasses. (2) Methods: the glasses based on 45S5 Bioglass®, are doped with 1.2 mol%, 3.6 mol% and 5.3 mol% of CeO2 and [...] Read more.
(1) Background: a cell evaluation focused to verify the self-regenerative antioxidant activity is performed on cerium doped bioactive glasses. (2) Methods: the glasses based on 45S5 Bioglass®, are doped with 1.2 mol%, 3.6 mol% and 5.3 mol% of CeO2 and possess a polyhedral shape (~500 µm2). Glasses with this composition inhibit oxidative stress by mimicking catalase enzyme (CAT) and superoxide dismutase (SOD) activities; moreover, our previous cytocompatibility tests (neutral red (NR), 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Bromo-2-deoxyUridine (BrdU)) reveal that the presence of cerium promotes the absorption and vitality of the cells. The same cytocompatibility tests were performed and repeated, in two different periods (named first and second use), separated from each other by four months. (3) Results: in the first and second use, NR tests indicate that the presence of cerium promotes once again cell uptake and viability, especially after 72 h. A decrease in cell proliferation it is observed after MTT and BrdU tests only in the second use. These findings are supported by statistically significant results (4) Conclusions: these glasses show enhanced proliferation, both in the short and in the long term, and for the first time such large dimensions are studied for this kind of study. A future prospective is the implantation of these bioactive glasses as bone substitute in animal models. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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13 pages, 4713 KiB  
Article
P2O5-Free Cerium Containing Glasses: Bioactivity and Cytocompatibility Evaluation
by Gigliola Lusvardi, Francesca Sgarbi Stabellini and Roberta Salvatori
Materials 2019, 12(19), 3267; https://doi.org/10.3390/ma12193267 - 08 Oct 2019
Cited by 10 | Viewed by 2872
Abstract
(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain [...] Read more.
(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain 1.2, 3.6, and 5.3 mol% of CeO2. Bioactivity and cytotoxicity tests were carried out in simulated body fluid (SBF) solution and murine osteocyte (MLO-Y4) cell lines, respectively. Leaching of ions concentration in SBF was determined by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). The surface of the glasses were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. (3) Results: P2O5-free cerium doped glasses are proactive according to European directives. Cerium increases durability and retards, but does not inhibit, (Ca10(PO4)6(OH)2, HA) formation at higher cerium amounts (K3.6 and K5.3); however, cell proliferation increases with the amount of cerium especially evident for K5.3. (4) Conclusions: These results enforce the use of P2O5-free cerium doped bioactive glasses as a new class of biomaterials. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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8 pages, 4723 KiB  
Article
Control of Dopant Distribution in Yttrium-Doped Bioactive Glass for Selective Internal Radiotherapy Applications Using Spray Pyrolysis
by Abadi Hadush Tesfay, Yu-Jen Chou, Cheng-Yan Tan, Fetene Fufa Bakare, Nien-Ti Tsou, E-Wen Huang and Shao-Ju Shih
Materials 2019, 12(6), 986; https://doi.org/10.3390/ma12060986 - 25 Mar 2019
Cited by 9 | Viewed by 2964
Abstract
In this study, we demonstrate the fabrication of Y-doped bioactive glass (BG), which is proposed as a potential material for selective internal radiotherapy applications. Owing to its superior bioactivity and biodegradability, it overcomes the problem of yttrium aluminosilicate spheres that remain in the [...] Read more.
In this study, we demonstrate the fabrication of Y-doped bioactive glass (BG), which is proposed as a potential material for selective internal radiotherapy applications. Owing to its superior bioactivity and biodegradability, it overcomes the problem of yttrium aluminosilicate spheres that remain in the host body for a long duration after treatment. The preparation of Y-doped BG powders were carried out using a spray pyrolysis method. By using two different yttrium sources, we examine the change of the local distribution of yttrium concentration. In addition, characterizations of phase information, particle morphologies, surface areas, and bioactivity were also performed. The results show that both Y-doped BG powders are bioactive and the local Y distribution can be controlled. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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15 pages, 23206 KiB  
Article
Cytocompatibility of Potential Bioactive Cerium-Doped Glasses based on 45S5
by Gianluca Malavasi, Roberta Salvatori, Alfonso Zambon, Gigliola Lusvardi, Luca Rigamonti, Luigi Chiarini and Alexandre Anesi
Materials 2019, 12(4), 594; https://doi.org/10.3390/ma12040594 - 16 Feb 2019
Cited by 25 | Viewed by 3323
Abstract
The cytocompatibility of potential bioactive cerium-containing (Ce3+/Ce4+) glasses is here investigated by preparing three different glasses with increasing amount of doping CeO2 (1.2, 3.6 and 5.3 mol% of CeO2, called BG_1.2, BG_3.6 and BG_5.3, respectively) based [...] Read more.
The cytocompatibility of potential bioactive cerium-containing (Ce3+/Ce4+) glasses is here investigated by preparing three different glasses with increasing amount of doping CeO2 (1.2, 3.6 and 5.3 mol% of CeO2, called BG_1.2, BG_3.6 and BG_5.3, respectively) based on 45S5 Bioglass® (called BG). These materials were characterized by Environmental Scanning Electron Microscopy (ESEM) and infrared spectroscopy (FTIR) after performing bioactivity tests in Dulbecco’s Modified Eagle Medium (DMEM) solution, and the ions released in solution were determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Optical Emission Spectrometry (ICP-OES). The data obtained clearly show that the glass surfaces of BG, BG_1.2 and BG_3.6 were covered by hydroxyapatite (HA), while BG_5.3 favored the formation of a cerium phosphate crystal phase. The cytotoxicity tests were performed using both murine long bone osteocyte-like (MLO-Y4) and mouse embryonic fibroblast (NIH/3T3) cell lines. The cerium-containing bioactive glasses show an increment in cell viability with respect to BG, and at long times, no cell aggregation and deformation were observed. The proliferation of NIH/3T3 cells increased with the cerium content in the glasses; in particular, BG_3.6 and BG_5.3 showed a higher proliferation of cells than the negative control. These results highlight and enforce the proposal of cerium-doped bioactive glasses as a new class of biomaterials for hard-tissue applications. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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Review

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38 pages, 962 KiB  
Review
A Review of Bioactive Glass/Natural Polymer Composites: State of the Art
by Rachele Sergi, Devis Bellucci and Valeria Cannillo
Materials 2020, 13(23), 5560; https://doi.org/10.3390/ma13235560 - 06 Dec 2020
Cited by 84 | Viewed by 6222
Abstract
Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which limit their applications. To [...] Read more.
Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which limit their applications. To tackle these drawbacks, collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose can be combined with bioactive glass (BG) nanoparticles and microparticles to produce composites. The incorporation of BGs improves the mechanical properties of the final system as well as its bioactivity and regenerative potential. Indeed, several studies have demonstrated that polymer/BG composites may improve angiogenesis, neo-vascularization, cells adhesion, and proliferation. This review presents the state of the art and future perspectives of collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose matrices combined with BG particles to develop composites such as scaffolds, injectable fillers, membranes, hydrogels, and coatings. Emphasis is devoted to the biological potentialities of these hybrid systems, which look rather promising toward a wide spectrum of applications. Full article
(This article belongs to the Special Issue Bioactive Glasses 2019)
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