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Novel Biomimetic Materials for Musculoskeletal Tissue Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 19735

Special Issue Editor


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Guest Editor
Department of Life Sciences, New York Institute of Technology, New York, NY, USA
Interests: muscululoskeletal development and regeneration; biomaterials

Special Issue Information

Dear Colleagues:

The regeneration of musculoskeletal tissues such as bone, cartilage, skeletal muscle tendons and ligaments are at the forefront of orthopaedic tissue engineering research. Finding ways to stimulate the regeneration of the aforementioned tissues in vivo, using innovative tissue engineering approaches and materials, is of utmost importance if we are to improve the lives of patients (both young and old). Presently, the approach includes a biofunctionalized natural or synthetic scaffold capable of providing the appropriate material/biomechanical properties while at the same time be biocompatible, porous, non-toxic and capable of stimulating cells to begin the tissue regeneration process. Clearly, various types of cells (fully differentiated, progenitors, stem, and even genetically modified), molecules (genes or proteins), and/or drugs can be used to functionalize the scaffolds and improve their success of inducing tissue regeneration. Many laboratories have taken advantage of this approach in order to engineer new bone, cartilage, skeletal muscle, tendons and ligaments, some with success. To this end, this special issue explores the latest research designed for constructing and testing unique biomimetic materials in order to stimulate regeneration of the various tissues of the musculoskeletal system. As the field is moving very rapidly, especially in the last decade or so, it is imperative that we monitor its progress by providing a forum for publishing the latest research. As such, I encourage you to submit your latest results in this research area for this Special Issue on “Novel Biomimetic Materials for Musculoskeletal Tissue Engineering”.

Full research papers, communications, and reviews are all welcome.

Prof. Michael Hadjiargyrou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bone
  • Cartilage
  • Skeletal muscle
  • Tendon
  • Ligament
  • Biomaterials
  • Regeneration
  • Scaffolds
  • Biomimetic

Published Papers (2 papers)

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Review

22 pages, 1250 KiB  
Review
Zinc as a Therapeutic Agent in Bone Regeneration
by J. Patrick O’Connor, Deboleena Kanjilal, Marc Teitelbaum, Sheldon S. Lin and Jessica A. Cottrell
Materials 2020, 13(10), 2211; https://doi.org/10.3390/ma13102211 - 12 May 2020
Cited by 129 | Viewed by 11776
Abstract
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. [...] Read more.
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic. Full article
(This article belongs to the Special Issue Novel Biomimetic Materials for Musculoskeletal Tissue Engineering)
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20 pages, 2857 KiB  
Review
Three-Dimensional Bioprinting of Cartilage by the Use of Stem Cells: A Strategy to Improve Regeneration
by Livia Roseti, Carola Cavallo, Giovanna Desando, Valentina Parisi, Mauro Petretta, Isabella Bartolotti and Brunella Grigolo
Materials 2018, 11(9), 1749; https://doi.org/10.3390/ma11091749 - 17 Sep 2018
Cited by 73 | Viewed by 7570
Abstract
Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a “layer-by-layer” deposition of small units [...] Read more.
Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a “layer-by-layer” deposition of small units of biomaterials and cells. This technique displays important advantages to mimic natural cartilage over traditional methods by allowing a fine control of cell distribution, and the modulation of mechanical and chemical properties. This opens up a number of new perspectives including personalized medicine through the development of complex structures (the osteochondral compartment), different types of cartilage (hyaline, fibrous), and constructs according to a specific patient’s needs. However, the choice of the ideal combination of biomaterials and cells for cartilage bioprinting is still a challenge. Stem cells may improve material mimicry ability thanks to their unique properties: the immune-privileged status and the paracrine activity. Here, we review the recent advances in cartilage three-dimensional, scaffold-based bioprinting using stem cells and identify future developments for clinical translation. Database search terms used to write this review were: “articular cartilage”, “menisci”, “3D bioprinting”, “bioinks”, “stem cells”, and “cartilage tissue engineering”. Full article
(This article belongs to the Special Issue Novel Biomimetic Materials for Musculoskeletal Tissue Engineering)
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