Innate Immunity Regulating Antigen Presentation

A special issue of Medical Sciences (ISSN 2076-3271). This special issue belongs to the section "Immunology and Infectious Diseases".

Deadline for manuscript submissions: closed (15 July 2018) | Viewed by 6558

Special Issue Editor

UCL Institute of Child Health, Molecular Immunology Unit, 30 Guilford Street, London, WC1N 1EH, UK
Interests: gamma/delta T-cells - innate and adaptive functions; tolerance induction in autoimmune diseases; natural antibodies in induction of adaptive immune responses

Special Issue Information

Dear Colleagues,

The immune system has, for a long time, been divided into two compartments, the innate and the adaptive. However, this division has mainly served the purposes of categorisation and simplification. The main idea with this Special Issue is to help in highlighting that it is at the interface of, and the integrated nature of, the innate and adaptive arms of the immune system where the key to a better understanding of the recognition of foreign and self antigens in health and disease lies.

Protein antigens are presented to T-cells with the help of Major Histocompatibility Complex (MHC) molecules, called HLA in humans. This is what regulates our T-cell responses, as well as much of our B-cell-derived antibody production. This MHC presentation of peptides to T-cells is, therefore, of crucial importance for many aspects of immune system activation and regulation. However, it is becoming increasingly clear that innate recognition of foreign, as well as ‘altered’ or ‘stressed’ self, are also communicated to, or actually performed by, the cells that do the MHC presentation. As they perform innate sensing functions, signalling to the MHC peptide processing and presentation pathways leads to careful regulation of what is communicated to T-cells. It is this integrated series of signalling and regulatory events with a huge potential impact in infectious disease and vaccination, in cancer, in autoimmunity, and in transplantation that we need to understand in greater detail. Whilst many of the details in this area are still very unclear, given the potential gains in many human disease areas from an increased understanding, we invite research article, as well as review contributions from leading investigators in the field, to communicate what they know and understand in this Special Issue entitled “Innate Immunity Regulating Antigen Presentation”.

Dr. Kenth Gustafsson
Guest Editor

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Published Papers (1 paper)

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Review

20 pages, 1891 KiB  
Review
Human Dendritic Cells: Ontogeny and Their Subsets in Health and Disease
by Sandra Georgina Solano-Gálvez, Sonia Margarita Tovar-Torres, María Sofía Tron-Gómez, Ariane Estrella Weiser-Smeke, Diego Abelardo Álvarez-Hernández, Giorgio Alberto Franyuti-Kelly, Mijail Tapia-Moreno, Antonio Ibarra, Laila Gutiérrez-Kobeh and Rosalino Vázquez-López
Med. Sci. 2018, 6(4), 88; https://doi.org/10.3390/medsci6040088 - 08 Oct 2018
Cited by 33 | Viewed by 6341
Abstract
Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population [...] Read more.
Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population of cells localized in different tissues where they act as sentinels continuously capturing antigens to present them to T cells. Dendritic cells are uniquely capable of attracting and activating naïve CD4+ and CD8+ T cells to initiate and modulate primary immune responses. They have the ability to coordinate tolerance or immunity depending on their activation status, which is why they are also considered as the orchestrating cells of the immune response. The purpose of this review is to provide a general overview of the current knowledge on ontogeny and subsets of human dendritic cells as well as their function and different biological roles. Full article
(This article belongs to the Special Issue Innate Immunity Regulating Antigen Presentation)
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