Microarrays for Drug Discovery and Development

A special issue of Microarrays (ISSN 2076-3905).

Deadline for manuscript submissions: closed (31 March 2017) | Viewed by 5450

Special Issue Editor


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Guest Editor
Cancer group, IICiMed, Faculté des Sciences et Techniques, Faculté de Pharmacie, Université de Nantes, F-44322 Nantes Cedex 3, France
Interests: drug discovery; cancer therapy; reactive molecules; protein binding; high throughput; microorganisms; plasmids; amino acid production

Special Issue Information

Dear Colleagues,

The diversity of microarrays and their technological advantages have gained importance in the solving of different problems at the early stages of Drug Discovery and Development (DDD), ranging from high-throughput screening of compound libraries to preclinical assays. Recent discovery of new target-specific leads and the development of disease-specific companion diagnostics are promising examples where microarrays might become indispensable tools for DDD. Moreover, cost-effective microarray applications provide the unique opportunity to create multifaceted pipelines with aim to reduce expenditures on DDD projects, an important challenge since some time.

This Special Issue will focus on microarray researches leading to discovery and development of therapeutic molecules, as small compounds, antibodies, proteins, peptides, and aptamers. You are invited to submit original papers and reviews describing screening of natural and chemical compound libraries, profiling protein expression and post-translational modification in cells exposed to pharmacophores, multiplex assays for target discovery or drug validation, and approaches for data mining. Contribution of microarrays to pharmacogenomics and pharmacoproteomics, including assessment of toxicity and other absorption, distribution, metabolism, and excretion (ADME) parameters with a perspective to improve the outcome of discovery projects, and to help in decision making regarding drug candidates for clinical assays, are also welcome.

Prof. Dr. Vehary Sakanyan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microarrays is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • drug development
  • microarrays
  • high-throughput screening
  • drug validation
  • pharmacogenomics
  • pharmacoproteomics

Published Papers (1 paper)

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Article
Microarray Selection of Cooperative Peptides for Modulating Enzyme Activities
by Jinglin Fu
Microarrays 2017, 6(2), 8; https://doi.org/10.3390/microarrays6020008 - 26 Apr 2017
Cited by 1 | Viewed by 5011
Abstract
Recently, peptide microarrays have been used to distinguish proteins, antibodies, viruses, and bacteria based on their binding to random sequence peptides. We reported on the use of peptide arrays to identify enzyme modulators that involve screening an array of 10,000 defined and addressable [...] Read more.
Recently, peptide microarrays have been used to distinguish proteins, antibodies, viruses, and bacteria based on their binding to random sequence peptides. We reported on the use of peptide arrays to identify enzyme modulators that involve screening an array of 10,000 defined and addressable peptides on a microarray. Primary peptides were first selected to inhibit the enzyme at low μM concentrations. Then, new peptides were found to only bind strongly with the enzyme–inhibitor complex, but not the native enzyme. These new peptides served as secondary inhibitors that enhanced the inhibition of the enzyme together with the primary peptides. Without the primary peptides, the secondary effect peptides had little effect on the enzyme activity. Conversely, we also selected peptides that recovered the activities of inhibited enzyme–peptide complex. The selection of cooperative peptide pairs will provide a versatile toolkit for modulating enzyme functions, which may potentially be applied to drug discovery and biocatalysis. Full article
(This article belongs to the Special Issue Microarrays for Drug Discovery and Development)
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