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Micromachines
Special Issues
Microfluidic Devices for Healthcare and Environment Monitoring
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Microfluidic Devices for Healthcare and Environment Monitoring

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 4183

Special Issue Editors

Dr. Xize Niu

E-Mail Website
Guest Editor
Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK
Interests: microfluidics and lab-on-a-chip; multiphase flow and droplet microfluidics; point-of-care devices; biosensor and sensor networks; sampling and microdialysis; microelectromechanical systems
Special Issues, Collections and Topics in MDPI journals
Dr. Adrian Nightingale

E-Mail Website
Guest Editor
Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK
Interests: microfluidics; field-deployable analysers; sensors; analytical chemistry; analytical technology; microfabrication; microreactors; emulsions; colloidal materials; materials characterisation

Special Issue Information

Dear Colleagues,

Developments in miniaturisation and lab-on-a-chips over recent decades have led to many novel analytical devices for “point-of-care” (POC) applications. POC devices can be used to accurately quantify a diverse range of analytes, most notably for medical samples, typically quantifying the concentration of a specified analyte at the moment of sampling. While useful for determining the condition of the sample at a fixed point in time, this poses a problem for any chemically-dynamic system, where transient changes cannot be detected or characterised. POC monitoring adopts a different approach—continuously measuring to give real-time information on changes in the system. For example, in a medical setting, this approach has been used to characterise neurotransmitter variations in the brain, metabolite changes in transplanted tissue. Likewise, in environmental science, microfluidic systems have been used to monitor and characterise nutrient dynamics in marine and river water. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on either novel methodological developments that enable POC-monitoring (e.g., developments in sampling, analysis) or cases where the technology has been applied, with particular interests being paid to applications in healthcare and environmental science, where continuous monitoring using microfluidics has already demonstrated potential.

Dr. Xize Niu
Dr. Adrian Nightingale
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • Sensor
  • Chemical monitoring
  • Healthcare
  • Environment
  • Point-of-care (POC)
  • Nutrient and pollutant in Water

Published Papers (1 paper)

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Research

10 pages, 2083 KiB  
Article
A Microfluidic Platform for Investigating Transmembrane Pressure-Induced Glomerular Leakage
by Ting-Hsuan Chen, Jie-Sheng Chen, Yi-Ching Ko, Jyun-Wei Chen, Hsueh-Yao Chu, Chih-Shuan Lu, Chiao-Wen Chu, Hsiang-Hao Hsu and Fan-Gang Tseng
Micromachines 2018, 9(5), 228; https://doi.org/10.3390/mi9050228 - 10 May 2018
Cited by 7 | Viewed by 3825
Abstract
Transmembrane pressure across the glomerular filter barrier may underlie renal failure. However, studies of renal failure have been difficult owing to a lack of in vitro models to capture the transmembrane pressure in a controlled approach. Here we report a microfluidic platform of [...] Read more.
Transmembrane pressure across the glomerular filter barrier may underlie renal failure. However, studies of renal failure have been difficult owing to a lack of in vitro models to capture the transmembrane pressure in a controlled approach. Here we report a microfluidic platform of podocyte culture to investigate transmembrane pressure induced glomerular leakage. Podocytes, the glomerular epithelial cells essential for filtration function, were cultivated on a porous membrane supplied with transmembrane pressure ΔP. An anodic aluminum oxide membrane with collagen coating was used as the porous membrane, and the filtration function was evaluated using dextrans of different sizes. The results show that dextran in 20 kDa and 70 kDa can penetrate the podocyte membrane, whereas dextran in 500 kDa was blocked until ΔP ≥ 60 mmHg, which resembles the filtration function when ΔP was in the range of a healthy kidney (ΔP < 60 mmHg) as well as the hypertension-induced glomerular leakage (ΔP ≥ 60 mmHg). Additionally, analysis showed that synaptopodin and actin were also downregulated when ΔP > 30 mmHg, indicating that the dysfunction of renal filtration is correlated with the reduction of synaptopodin expression and disorganized actin cytoskeleton. Taking together, our microfluidic platform enables the investigation of transmembrane pressure in glomerular filter membrane, with potential implications for drug development in the future. Full article
(This article belongs to the Special Issue Microfluidic Devices for Healthcare and Environment Monitoring)
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