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Special Issue "Cyclodextrin Chemistry 2018"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 April 2018

Special Issue Editor

Guest Editor
Prof. Dr. Bernard Martel

Unité Matériaux et Transformations (UMET) UMR CNRS 8207, Universite des Sciences et Technologies de Lille, Villeneuve d'Ascq Cedex, France
Website | E-Mail
Interests: cyclodextrin polymers; functional textiles; water decontamination; biomaterials; drug delivery systems; antibacterial materials

Special Issue Information

Dear Colleagues,

Cyclodextrins (CDs) are a family starch derivates discovered by Villiers in 1891, of which a cyclic structure was evidenced in the 1930s by Freudenberg, followed by the exploration of their remarkable encapsulation properties from the 1950–1970. Cyclodextrins applications have, thereafter, increased, involving many academic and industrial researchers who have published up to 40,000 papers (including more than 2000 in 2016) and almost 800 patents (Scopus source) up to now. Studies and applications firstly focused on "native" alpha/beta/gamma-cyclodextrins, but chemists have rapidly tuned their properties through chemical modifications with substituent groups, polymerization reactions, and materials surfaces modifications. Furthermore, the versatility of cyclodextrins was still extended thanks to the emergence of nanotechnologies. This "modern period" has paved the way for increasing application fields of cyclodextrins, such as biotechnologies, soil remediation, wastewaters treatment, analytical chemistry, drug vectorization and drug delivery, pharmaceutical excipients, flavor and fragrance stabilization, controlled release, biomaterials, homogeneous, biphasis and heterogeneous catalysis, self-healing materials, etc. Such versatile properties of cyclodextrins explain why cyclodextrins have attracted a great deal of interest in a variety of industries, including those related to food, pharmaceuticals, cosmetics, chemicals, and agriculture. This Special Issue on cyclodextrin chemistry aims to provide a forum for the dissemination of the latest information on new chemical methods for access to advanced cyclodextrins-based systems, useable in the aforementioned application domains and industries.

Prof. Dr. Bernard Martel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cyclodextrins in advanced materials
  • cyclodextrins based stimuli-responsive systems
  • green chemistry processes based on cyclodextrins
  • cyclodextrins based catalysts
  • syntheses of cyclodextrins derivates and polymers
  • applications of cyclodextrins in food
  • cyclodextrins-based hydrogels
  • cosmetic formulations
  • cyclodextrin for vectorization and/or controled release of active substances
  • cyclodextrins involved in environmental depollution (air, soils, waste waters, sediments)
  • nano materials and nano-structured coatings containing cyclodextrins

Published Papers (1 paper)

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Open AccessFeature PaperConcept Paper Development of Dipicolylamine-Modified Cyclodextrins for the Design of Selective Guest-Responsive Receptors for ATP
Molecules 2018, 23(3), 635; doi:10.3390/molecules23030635 (registering DOI)
Received: 27 February 2018 / Revised: 9 March 2018 / Accepted: 11 March 2018 / Published: 12 March 2018
PDF Full-text (3328 KB) | HTML Full-text | XML Full-text | Supplementary Files
The construction of supramolecular recognition systems based on specific host–guest interactions has been studied in order to design selective chemical sensors. In this study, guest-responsive receptors for ATP have been designed with cyclodextrins (CyDs) as a basic prototype of the turn-on type fluorescent
[...] Read more.
The construction of supramolecular recognition systems based on specific host–guest interactions has been studied in order to design selective chemical sensors. In this study, guest-responsive receptors for ATP have been designed with cyclodextrins (CyDs) as a basic prototype of the turn-on type fluorescent indicator. We synthesized dipicolylamine (DPA)-modified CyD–Cu2+ complexes (Cu·1α, Cu·1β, and Cu·1γ), and evaluated their recognition capabilities toward phosphoric acid derivatives in water. The UV-Vis absorption and fluorescence spectra revealed that Cu·1β selectively recognized ATP over other organic and inorganic phosphates, and that β-CyD had the most suitable cavity size for complexation with ATP. The 1D and 2D NMR analyses suggested that the ATP recognition was based on the host–guest interaction between the adenine moiety of ATP and the CyD cavity, as well as the recognition of phosphoric moieties by the Cu2+–DPA complex site. The specific interactions between the CyD cavity and the nucleobases enabled us to distinguish ATP from other nucleoside triphosphates, such as guanosine triphosphate (GTP), uridine triphosphate (UTP), and cytidine triphosphate (CTP). This study clarified the basic mechanisms of molecular recognition by modified CyDs, and suggested the potential for further application of CyDs in the design of highly selective supramolecular recognition systems for certain molecular targets in water. Full article
(This article belongs to the Special Issue Cyclodextrin Chemistry 2018)

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