Dear Colleagues,

The development of artificial DNA-binding agents represents a significant intellectual challenge at the crossroads between biology and chemistry (structural, supramolecular, organic, inorganic chemistry, etc.) that offers ample ground for creativity. Thus, inspired by natural proteins that modulate protein expression by interacting with specific sequences, researchers have developed increasingly sophisticated DNA-binding agents that not only display comparable affinity and selectivity, but are also endowed with novel properties not found in their natural counterparts, such as light-activation, fluorescence emission, or catalytic properties.

In this Special Issue of Molecules on “DNA Recognition” we aim at providing a general overview of the field from a chemical perspective, covering from designed peptides and small organic DNA-binding agents to metal complexes and supramolecular, dynamic, and switchable systems. We hope that this Special Issue will not only provide a panorama of the field in its current form but will also offer a perspective of the challenges and developments ahead.

Dr. M. Eugenio Vázquez
Guest Editor

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• DNA recognition
• chemical biology
• DNA-binding agents
• molecular recognition
• supramolecular chemistry