Recent Developments in Using Biocatalysts and Whole Cells for Organic Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (15 October 2016) | Viewed by 11200
Special Issue Editor
Special Issue Information
Dear Colleagues,
The use of biocatalysts and whole cells as efficient catalysts for organic transformations represents an extremely important strategy for the preparation of complex organic products, with many bioprocesses having been carried out on an industrial scale. Given their importance, this Special Issue invites submission of papers on new research that describes the application of biocatalysts/whole cells for the transformation of organic substrates into valuable organic products. Potential examples could include the use of biocatalysts/whole cells to transform prochiral substrates into chiral products, protocols for the kinetic resolution/desymmetrisation of racemic/meso substrates, selective protection/deprotection reactions of substrates containing multiple functional groups, and remote functionalisation reactions. Applications where molecular biology techniques have been used to improve the performance of biocatalysts, or produce new biocatalytic activities are particularly welcome, as are synthetic biology studies that afford new organisms capable of producing synthetically useful organic products. Reviews of specific areas of biocatalysis, biotransformations and synthetic biology applied to organic synthesis and perspectives on potential future applications will also be considered for publication.
Prof. Dr. Steven Bull
Guest Editor
Manuscript Submission Information
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Keywords
- Chemo-enzymatic synthesis
- New biocatalytic transformations applied to organic synthesis
- Biocatalytic protocols for the synthesis of chiral products
- Kinetic resolution strategies
- Desymmetrisation strategies
- Protection/deprotection strategies
- Biocatalytic coupling reactions
- Remote functionalisation reactions
- Technological developments (e.g. immobilisation/flow biocatalysis/ new reactor design, etc.)
- Biocatalysis in organic solvents
- Site-directed mutagenesis to improve biocatalyst performance
- Directed evolution to improve biocatalytic activity/selectivity profiles
- New screening techniques to identify useful biocatalytic activities
- Whole cell biotransformations applied to organic synthesis
- Identification of new enzymes/organisms with useful biocatalytic activity
- Synthetic biology studies applied to the production of organic products
