Special Issue "DNA-Templated Synthesis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 November 2011)
Prof. Dr. Satoshi Obika
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
Interests: bioorganic chemistry; nucleic acid chemistry; organic synthesis; medicinal chemistry
In a living cell, many kinds of bioactive compounds are selectively and effectively synthesized, although there are thousands of reactants/products in the cell, namely, a reaction vessel. It is amazing but not magic. Nature controls the reactivity of these compounds by using macromolecules as a template of the reaction where only the necessary reactants come close each other to afford the desired products selectively. One important example of the “nature’s effective-molarity-based approach” is the nucleic acid-templated reaction. In the transcription of DNA, ribonucleotides are coupled on the templated DNA to form messenger RNA, while amino acids connected to the ribosomal RNA are coupled on the templated RNA to give proteins. Thus, nucleic acids work as a good template for the synthesis of bioactive compounds in a living cell. DNA-templated synthesis using the “nature’s effective-molarity-based approach” has attracted considerable attention in many fields of chemistry, such as organic chemistry, nucleic acids chemistry, bioorganic chemistry, analytical chemistry and medicinal chemistry. In fact, some pioneering works on the DNA-templated synthesis have been carried out so far. Among them, 1) DNA-templated synthesis for oligonucleotide linkage, and 2) DNA-templated organic synthesis are well known. The former includes the application to novel DNA analysis methods, and the latter includes the development of novel organic reactions or bioactive compounds. In addition, the design and synthesis of well-defined nanoscale architecture via DNA-templated self-assembly is also of great interest to nano science and nano technology. This Special Issue of Molecules will consider any submissions associated with DNA-Templated Synthesis in any form. I strongly encourage authors to submit manuscripts for this Special Issue.
Prof. Dr. Satoshi Obika
- template synthesis
- nucleic acid analogues
- sequence analysis
- single nucleotide polymorphism
- chemical ligation
- chemical library synthesis
- DNA-encoded chemical library
- small molecules
- combinatorial chemistry
- molecular evolution
- bioactive compounds
- DNA-templated self assembly
- nano technology