Special Issue "Diversity Oriented Synthesis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2011)
In many ways, Diversity-Oriented Synthesis (DOS) represents the conceptualization and expansion of some long-established research principles in medicinal chemistry and drug discovery. The physicochemical metrics that allow us to evaluate the structural similarity within a set of organic molecules often fall short in capturing the essence of the 3-dimensional array of functional groups that the chemist’s eye looks recognizes. In particular, there is a major discrepancy between theory and utility if these metrics are mainly based on generic descriptors such as molecular weight and logP, which tend to cluster in a narrow range. Research in applying the tools of organic synthesis to the construction of scaffold and stereochemical diversity in small organic molecules has never been so active, benefiting from decades of natural products chemistry and advances in multicomponent and pericyclic reactions, as well as asymmetric catalysis. Many of the resulting new organic products are finding their way into public and industrial high throughput screening programs, and therefore serve to link chemical and biological space.
This Special Issue on Diversity-Oriented Synthesis will offer an attractive forum to present the synthesis, structural and cheminformatics analysis, pharmacology and therapeutic potential offered by new and innovative molecular architectures. I strongly encourage authors to submit papers for this Special Issue on DOS, within the scope of Molecules. I hope that the topics covered will reflect the potential and the excitement of DOS in the chemical community.
Dr. Peter Wipf
- natural product-like agents
- molecular scaffolds
- stereodivergence and stereoselectivity
- multicomponent reactions
- pericyclic processes
- chemical library synthesis
- diversity analysis
- probe molecules
- biological screening