Special Issue "Enzyme-Catalyzed Reactions"
Deadline for manuscript submissions: closed (10 November 2014)
Prof. Dr. Lajos Novak
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, Szt. Geller ter 4, Hungary
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Interests: synthetic organic chemistry; rearrangement reactions; enzyme-catalyzed reaction, insect pheromone; insect growth regulators; lipoxygenase enzyme inhibitors; tryptamine derivatives
To generate chirality is essential in synthetic organic chemistry, medicinal chemistry and drug discovery. Besides conventional chemical synthetic methods, enzymes offer an excellent tool for asymmetric synthesis and enantioselective resolution. Enzyme-catalyzed reactions show excellent chemo-, region-, and stereocontrol. Furthermore, these reactions generally proceed at room temperature at pH≈ 7, in water and don’t require protecting-group manipulations. Considering the advantage of the enzyme catalyzed reactions, this technique may be widely used in chemical and biological research.
This Special Issue on enzyme-catalyzed reactions will offer a good possibility to illustrate the asymmetric catalysis with enzyme, its application in organic synthesis, and the mechanistic principles that govern these reactions. I strongly encourage authors to submit manuscripts for this Special Issue.
Dr. Lajos Novak
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- immobilized enzyme
- enzyme engineering
- cofactors and coenzymes
- industrial applications
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Linking Protein Motions to Enzyme Catalysis
Authors: Priyanka Narendra Singh, Don Thelma Abeysinghe, and Amnon Kohen
Affiliations: Department of Chemistry, The University of Iowa, Iowa City, IA 52242, USA
Abstract: Enzyme motions on a broad range of time scales can play an important role in various intermolecular events including substrate binding and product release in achieving the catalyzed chemical conversion. Therefore, the relationship between protein motions and the catalytic activity is of contemporary interest in enzymology. To understand the factors influencing the rates of enzyme catalyzed reactions, it has become apparent that dynamics of protein as well as its environment must be considered. The current review presents two case studies of enzymes: dihydrofolate reductase (DHFR) and thymidylate synthase (TSase), and discuss the role of protein motions in catalyzed reaction. We will discuss the use of kinetic isotope effect as an effective tool in probing such a role in the enzyme-catalyzed reactions.