Foldamers: Synthesis and Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (10 May 2017)
Special Issue Editor
Interests: conformationally restricted isosteres of natural amino acids; synthesis of cyclic monomers for foldamers via cyclofunctionalization reactions; design and preparation of novel atropisomers; α-hydrazido acids displaying significant antibiotic activity
Special Issue Information
Dear Colleagues,
Investigations concerning the protein folding led to development of compounds that were named “foldamers”. This definition deals with oligomers that display a secondary structure, mostly evidenced by spectroscopic methods, exploiting non-covalent interactions such as hydrogen bonding and aromatic stacking. Thus, a lot of different structures were obtained, although helices were most frequently observed. Moreover, it is worth mentioning that these compounds display interesting properties in disrupting protein–protein interactions, so that they are largely studied as drug candidates, being suitable for a novel approach to innovative therapeutics.
Prof. Dr. Mario Orena
Guest Editor
Manuscript Submission Information
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Keywords
- Building blocks
- β- and γ-peptides
- De novo design
- Aromatic foldamers
- Pseudopeptides
- Oligourea foldamers
