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Glycotherapeutics: Emerging Roles of Glycans in Medicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (30 May 2019) | Viewed by 3434

Special Issue Editor


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Guest Editor
Division of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
Interests: protein-carbohydrate interactions; lectins; glycosidases; carbohydrate microarrays; multivalency; bacterial adhesion; viral adhesion; O-GlcNAcylation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbohydrates play important roles in nature, and our understanding of them is increasing rapidly. Many recognition processes involving carbohydrates are of importance for proper functioning of biological systems. Similarly, carbohydrate recognition is, in many cases, part of disease. It is natural to expect that compounds affecting protein carbohydrate interactions have therapeutic potential. Thus far, this has only been seen for a select number of striking cases. In this Special Issue we welcome contributions that are involved in interference with disease causing processes. Timely topics in this area include the development of glycomimetics, covalent capture, multivalency, synthetic carbohydrate-based vaccines, antiadhesion of pathogens (viral, bacterial fungal), fluorosugars, iminosugars and others. 

Prof. Dr. Roland J. Pieters
Guest Editor

Manuscript Submission Information

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Keywords

  • protein-carbohydrate interactions
  • inhibitors
  • glucomimetics
  • multivalency
  • bacterial adhesion
  • viral adhesion
  • iminosugars
  • fluorosugars
  • carbohydrate vaccins
  • bacterial toxin inhibition

Published Papers (1 paper)

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Research

12 pages, 2070 KiB  
Article
Lactosylated Albumin Nanoparticles: Potential Drug Nanovehicles with Selective Targeting Toward an In Vitro Model of Hepatocellular Carcinoma
by Nayelli Guadalupe Teran-Saavedra, Jose Andre-i Sarabia-Sainz, Erika Silva-Campa, Alexel J. Burgara-Estrella, Ana María Guzmán-Partida, Gabriela Ramos-Clamont Montfort, Martín Pedroza-Montero and Luz Vazquez-Moreno
Molecules 2019, 24(7), 1382; https://doi.org/10.3390/molecules24071382 - 09 Apr 2019
Cited by 10 | Viewed by 2985
Abstract
Hepatocellular carcinoma (HCC) ranks fifth in occurrence and second in mortality of all cancers. The development of effective therapies for HCC is urgently needed. Anticancer drugs targeted to the liver-specific asialoglycoprotein receptors (ASGPRs) are viewed as a promising potential treatment for HCC. ASGPRs [...] Read more.
Hepatocellular carcinoma (HCC) ranks fifth in occurrence and second in mortality of all cancers. The development of effective therapies for HCC is urgently needed. Anticancer drugs targeted to the liver-specific asialoglycoprotein receptors (ASGPRs) are viewed as a promising potential treatment for HCC. ASGPRs facilitate the recognition and endocytosis of molecules, and possibly vehicles with galactose end groups, by the liver. In this study, bovine serum albumin (BSA) was conjugated with lactose using a thermal treatment. The formation of lactosylated BSA (BSA-Lac) was confirmed by a change of the chemical structure, increased molecular mass, and Ricinus communis lectin recognition. Subsequently, the low-crosslinking BSA-Lac nanoparticles (LC BSA-Lac NPs) and high-crosslinking BSA-Lac nanoparticles (HC BSA-Lac NPs) were synthesized. These nanoparticles presented spherical shapes with a size distribution of 560 ± 18.0 nm and 539 ± 9.0 nm, as well as an estimated surface charge of −26 ± 0.15 mV and −24 ± 0.45 mV, respectively. Both BSA-Lac NPs were selectively recognized by ASGPRs as shown by biorecognition, competition, and inhibition assays using an in vitro model of HCC. This justifies pursuing the strategy of using BSA-Lac NPs as potential drug nanovehicles with selective direction toward hepatocellular carcinoma. Full article
(This article belongs to the Special Issue Glycotherapeutics: Emerging Roles of Glycans in Medicine)
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