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Special Issue "Transition Metals Catalysis"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (20 September 2012)

Special Issue Editors

Guest Editor
Prof. Jin-Quan Yu

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
Website | E-Mail
Interests: transition metal-catalyzed C-H activation
Guest Editor
Dr. Ramesh Giri

Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, MN 87131, USA
Website | E-Mail
Interests: developing transition metal-catalyzed reactions; investigation of reaction mechanisms

Special Issue Information

Dear Colleagues,

Transition metal catalysis represents the core of modern-day synthetic methodology, which is being extensively exploited in both laboratory and industrial settings. Its applications, which range from manufacturing ingredients for cosmetic products to generating bioactive molecules for drug discovery, stand testimony to the critical roles a transition metal-catalyzed process plays in meeting our growing needs for efficient chemical technology. Discovery of such a catalytic process is often guided by aspirations for developing novel organic transformations and replacing existing, inefficient processes. In recent years, high throughput screenings and mechanism-guided reaction investigations, often augmented by theoretical calculations, have provided breeding grounds for the growth of new catalytic transformations. Moreover, mechanistic understanding, gleaned from the studies of known transition metal-catalyzed reactions, is also serving as a blueprint both for the rational design of improved catalysts aimed at developing catalysts with high turnover numbers (TON) and selectivity, and for the conception of novel organometallic catalysis tailored to solve specific problems in organic synthesis.
This Special Issue on Transition Metals Catalysis is anticipated to showcase representative state-of-the-art developments in all aspects of transition metal-catalyzed reactions. Therefore, contributions are invited in all themes, including but not limited to reaction discovery, mechanistic study and catalyst design.

Prof. Jin-Quan Yu
Dr. Ramesh Giri
Guest Editors

Keywords

  • organotransition metal complexes
  • catalyst design
  • homogeneous and Heterogeneous catalysis
  • cross‒coupling reactions
  • synthetic tools
  • selectivity
  • inter‒ and intramolecular reactions
  • bioorganometallic Chemistry

Published Papers (3 papers)

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Research

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Open AccessCommunication Palladium-Catalyzed Multicomponent Synthesis of 2-Imidazolines from Imines and Acid Chlorides
Molecules 2012, 17(12), 13759-13768; doi:10.3390/molecules171213759
Received: 25 October 2012 / Revised: 13 November 2012 / Accepted: 14 November 2012 / Published: 22 November 2012
Cited by 4 | PDF Full-text (289 KB) | Supplementary Files
Abstract
We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl3 is found to result in a mixture of imidazolinium and
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We describe the palladium-catalyzed multicomponent synthesis of 2-imidazolines. This reaction proceeds via the coupling of imines, acid chlorides and carbon monoxide to form imidazolinium carboxylates, followed by a decarboxylation. Decarboxylation in CHCl3 is found to result in a mixture of imidazolinium and imidazolium salts. However, the addition of benzoic acid suppresses aromatization, and generates the trans-disubstituted imidazolines in good yield. Combining this reaction with subsequent nitrogen deprotection provides an overall synthesis of imidazolines from multiple available building blocks. Full article
(This article belongs to the Special Issue Transition Metals Catalysis)

Review

Jump to: Research

Open AccessReview New Advances in Titanium-Mediated Free Radical Reactions
Molecules 2012, 17(12), 14700-14732; doi:10.3390/molecules171214700
Received: 31 October 2012 / Revised: 28 November 2012 / Accepted: 6 December 2012 / Published: 11 December 2012
Cited by 28 | PDF Full-text (781 KB)
Abstract
Titanium complexes have been widely used as catalysts for C‑C bond-forming processes via free-radical routes. Herein we provide an overview of some of the most significant contributions in the field, that covers the last decade, emphasizing the key role played by titanium salts
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Titanium complexes have been widely used as catalysts for C‑C bond-forming processes via free-radical routes. Herein we provide an overview of some of the most significant contributions in the field, that covers the last decade, emphasizing the key role played by titanium salts in the promotion of selective reactions aimed at the synthesis of multifunctional organic compounds, including nucleophilic radical additions to imines, pinacol and coupling reactions, ring opening of epoxides and living polymerization. Full article
(This article belongs to the Special Issue Transition Metals Catalysis)
Open AccessReview Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles
Molecules 2012, 17(11), 13235-13252; doi:10.3390/molecules171113235
Received: 19 September 2012 / Revised: 29 October 2012 / Accepted: 1 November 2012 / Published: 6 November 2012
Cited by 19 | PDF Full-text (1366 KB)
Abstract
Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block
[...] Read more.
Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO–CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process. Full article
(This article belongs to the Special Issue Transition Metals Catalysis)

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