Peptides as Candidate Chemotherapeutic Drugs
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (10 May 2016) | Viewed by 5868
Special Issue Editor
Special Issue Information
Dear Colleagues,
Peptides, whether derived from natural or non-natural amino acids, hold enormous potential as drug molecules due to their ability to serve as surrogate substrates or interaction partners of proteins that are relevant drug targets. While there are many peptide drugs approved for clinical use, this chemical class still lags, in number, behind small molecules and therapeutic proteins (including antibodies). Peptides suffer from the stigma of displaying generally poor pharmacokinetic properties, including poor bioavailability, absorption, and short in vivo
half-life, and the potential for expensive large scale production. In the last several decades, strategies and techniques have been developed to deal with these concerns. In recent years there has been resurgent interest in peptides as drug molecules. This Special Issue of Molecules aims to present advances in addressing unique difficulties in development of peptides as drugs for the traditional chemotherapy areas of anti-infective agents and cancer. We welcome submission of original research papers, as well as reviews for this issue.
Dr. Wade A. Russu
Guest Editor
Manuscript Submission Information
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Keywords
- peptides
- peptide synthesis
- chemotherapy
- anti-infective
- anticancer
- drug development
- drug targeting
