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Special Issue "Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 16 August 2018

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. Wenxu Zhou

Department of Chemistry and Biochemistry, Center for Chemical Biology (CCB), Texas Tech University, Lubbock, TX 79409, USA
Website | E-Mail
Interests: sterol; antifungal; sterol biosynthesis; sterol auxotrophy; metabolomics
Guest Editor
Prof. Dr. De-an Guo

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China
Website | E-Mail
Interests: natural products chemistry; phytochemical analysis; herbal quality control; biotransformation; pharmacokinetics

Special Issue Information

Dear Colleagues,

Dr. W. David Nes is an eminent sterol biochemist who has made seminal contributions to the areas of chemical analysis, biosynthesis, and mechanistic enzymology. His fundamental research has led to the isolation and synthesis of over 300 sterols and triterpenoids, to a greater understanding of sterol diversity and function across kingdoms, and new knowledge for catalytic competence and three-dimensional structures of sterol biosynthesis enzymes. He developed significant collaborations in the US and abroad to advance steroidal inhibitors for the treatment of fungal and protozoan diseases. Dr. W. David Nes is currently a Paul Whitfield Horn Professor of Chemistry & Biochemistry at Texas Tech University, Lubbock, Texas. He received his BA from Gettysburg College (1975), MS from Drexel University (1977), and PhD from the University of Maryland, College Park (1979). He completed post-doctoral studies at the University of California, Berkeley and at the ARS-USDA regional laboratory in Albany CA during years 1979 to 1982. He continued on in the Plant Physiology and Chemistry Research Unit in Albany and then in the Microbial Products Research Unit at the USDA laboratory in Athens, GA until 1993 as Lead Research Chemist. In 1993, he moved to the Department of Chemistry & Biochemistry and was promoted to Horn professor in 2007. From 1999 to 2016, he was Division Chair of Biochemistry, and from 2012 to 2016, Director of the Center for Chemical Biology at Texas Tech University. He took a two-year leave of absence from the university during the period 2003–2005 to be Program Director of Molecular Biochemistry in the Division of Molecular and Cellular Biosciences at the National Science Foundation.

Professor Nes has received several awards for research excellence while at the USDA and at Texas Tech University, including the Barnie E. Rushing Jr. Award for Research Excellence. He has received an Honorable Guest Professorship (Peking University, China, 1995), Advanced Distinguished Lectureship (Kansas State University, 2010), DAAD fellowship from Germany (1982), and was sponsored by several members of the National Academy of Sciences and Royal Society to publish papers in PNAS and Proc. R. Soc. and contributed papers to special issues honoring members of the US National Academy of Sciences. During his career, he has held adjunct professor positions in the chemistry department at Auburn University (1988–1993) and the Natural Product Institute at the University of Georgia (1991–1993). He has held Visiting Professorships at the Institute for Chemical Ecology (Max Planck Institute, Jena, Germany 2007) and Centre for Cytochrome P-450 Biodiversity (College of Medicine, Swansea University, Wales, 2013) and Professorship in the Department of Immunology and Molecular Microbiology (Texas Tech Health Sciences Center School of Medicine, 2013–2017) and has served on the editorial boards of high-impact journals and on a range of federal panels, including the National Institutes of Health and National Science Foundation. He has been funded by USDA, NIH, NSF, Welch Foundation and Industry, including AstraZeneca Pharmaceuticals, Norvatis, Monsanto, and Bayer Crops, and mentored 30 MS and PhD students and 43 Post-doctoral fellows and Visiting Scientists. His high H-index is reflective of his >200 publications and eight books, many of which are among some of the highly cited or considered classics.

Molecules is highly pleased to host a Special Issue, and invites scientists to submit original contributions to “Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday”.

Assoc. Prof. Dr. Wenxu Zhou
Prof. Dr. De-an Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sterol
  • sterol biosynthesis
  • natural products
  • isoprenoids
  • cholesterol
  • phytosterol
  • lipidomics
  • enzymology/enzyme mechanisms
  • ergosterol biosynthesis inhibitors
  • drug therapy
  • CYP51
  • sterol C24-methyltransferase
  • suicide substrate
  • transition state analog
  • antifungal
  • anti-parasite drugs
  • sparking function
  • chemical analysis
  • eukaryotic pathogen
  • sterol evolution
  • sterol auxotroph

Published Papers (1 paper)

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Open AccessArticle Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities
Molecules 2018, 23(2), 315; doi:10.3390/molecules23020315
Received: 9 December 2017 / Revised: 30 January 2018 / Accepted: 31 January 2018 / Published: 2 February 2018
PDF Full-text (770 KB) | HTML Full-text | XML Full-text | Supplementary Files
Nine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo-[6]-shogaol (1), (Z)-6-oxo-[8]-shogaol (2), (Z)-6-oxo-[10]-shogaol (3)], one 6-oxoparadol derivative [6-oxo-[6]-paradol (4)], one isoshogaol derivative [(E)-[4]-isoshogaol (5)], and four
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Nine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo-[6]-shogaol (1), (Z)-6-oxo-[8]-shogaol (2), (Z)-6-oxo-[10]-shogaol (3)], one 6-oxoparadol derivative [6-oxo-[6]-paradol (4)], one isoshogaol derivative [(E)-[4]-isoshogaol (5)], and four paradoldiene derivatives [(4E,6Z)-[4]-paradoldiene (8), (4E,6E)-[6]-paradoldiene (9), (4E,6E)-[8]-paradoldiene (10), (4E,6Z)-[8]-paradoldiene (11)], together with eight known analogues, were isolated from the rhizoma of Zingiber officinale. Their structures were elucidated on the basis of spectroscopic data. It was noted that the isolation of 6-oxo-shogaol derivatives represents the first report of gingerols containing one 1,4-enedione motif. Their structures were elucidated on the basis of spectroscopic and HRESIMS data. All the new compounds were evaluated for their cytotoxic activities against human cancer cells (MCF-7, HepG-2, KYSE-150). Full article

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