Material Properties Underpinning Nanotoxicity Studies and Safety by Design Strategies

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (28 February 2018) | Viewed by 8699

Special Issue Editors


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Guest Editor
School of Geography, Earth and Environmental Sciences, University of Birmingham Edgbaston, Birmingham B15 2TT, UK
Interests: environmental interactions of nanoparticles and nanostructured surfaces; nanomaterials safety assessment; fate and sustainable future of plastics; environmental pollution
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Geography, Earth and Environmental Science, University of Birmingham, Birmingham B15 2TT, UK
Interests: nanomaterial properties; reactivity; toxicity; solubility; bio-nano interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of Safety by Design (SbD) was established to help the development of nanoparticles and materials with risk minimisation at every stage of the design process to achieve long term commercial potential and consumer confidence. Similarly, concepts around green nanomaterials and Benign by design (BbD) reflect the need the need to reduce reliance on critical non-renewable resources and to move away from the single-use culture towards a more circular economy. Together these concepts will help nanosafety and Environmental Health and Safety (EHS) consideration to keep up with innovation, and indeed merge into so-called “safe innovation”.

At the heart of SbD/BbD lies the concept of substituting the question “Is it safe/sustainable?” with “Can we engineer it to be safe/sustainable?” This Special Issue of Nanomaterials will attempt to cover the recent advances in the design of safe (lower hazard, exposure or persistence) and/or benign (green, recyclable, re-usable, lower impacts across the whole life cycle) nanomaterials, focussing on those molecular and physico-chemical properties (intrinsic and extrinsic to the material) driving hazard or exposure (and thus risk) and on strategies to design-out, replace, substitute or mitigate the undesirable effects whilst retaining functionality and cost-efficiency.

Prof. Dr. Iseult Lynch
Prof. Dr. Eugenia (Éva) Valsami-Jones
Guest Editors

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Keywords

  • nanomaterials    
  • nanocomposites  
  • nano-hybrids    
  • nanosafety    
  • hazard assessment    
  • risk assessment    
  • classification    
  • grouping    
  • safe-by-design    
  • benign-by-design    
  • predictive toxicology

Published Papers (1 paper)

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Research

24 pages, 8075 KiB  
Article
Characterization of Nanoparticle Batch-To-Batch Variability
by Sonja Mülhopt, Silvia Diabaté, Marco Dilger, Christel Adelhelm, Christopher Anderlohr, Thomas Bergfeldt, Johan Gómez de la Torre, Yunhong Jiang, Eugenia Valsami-Jones, Dominique Langevin, Iseult Lynch, Eugene Mahon, Inge Nelissen, Jordi Piella, Victor Puntes, Sikha Ray, Reinhard Schneider, Terry Wilkins, Carsten Weiss and Hanns-Rudolf Paur
Nanomaterials 2018, 8(5), 311; https://doi.org/10.3390/nano8050311 - 08 May 2018
Cited by 61 | Viewed by 8062
Abstract
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and [...] Read more.
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced. Full article
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