Dear Colleagues,

 Proteomics offers a wide range of opportunities to investigate malignancy-associated molecular alterations at the functional level and has stimulated great interest in applying the technology to study cancers and associated diseases. Malignancy-associated proteome alterations in a biological system, localized or systemic, related to or discrete from genomic mutations, may reflect the profound changes in cellular functions and biological processes at multiple levels. These steady or perturbation-induced proteome alterations may include changes on protein expressional level, sequence, status of post-translational modifications (PTMs), protein interaction networks, and cellular localization. In the past two decades, enormous efforts have been increasingly applied in cancer proteomics, with research goals ranging from mechanistic study to biomarker development, as well as to clinical applications. A variety of cancer and control samples, including cell lines and derivatives, tumor tissues and isolated cells, plasma/serum and other bodily fluids, have been investigated. These studies have laid important foundations for future cancer proteomics studies. With the recent advances in mass spectrometry technology, bioinformatics and knowledgebase, the depth, breadth and robustness of proteomics have been significantly improved. The emerging fields in PTM analysis, proteogenomics, single cell proteomics and spectral library-based proteomics, such as SWATH, carry great potentials for basic, translational and clinical cancer research. We welcomes submissions of original research or review articles aiming at the broad field of cancer research using proteomics approaches.  Prof. Dr. Sheng Pan

Prof. Dr. Sheng Pan
Guest Editor

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• proteomics
• cancer
• mass spectrometry
• post-translational modifications