Dear Colleagues,

During the last decade, proteome research has been shown to benefit clinical diagnostics and able to predict the outcome of several diseases. Complex biological samples can be analysed using several proteomic platforms, although in most cases a pre-fractioning of proteins and peptides is of the utmost importance. Thus, methods covering this process have been studied extensively over the last few decades. In haematology, several platforms and body fluids have been used to diagnose/predict the development of complications after allogeneic stem cell transplantation. While older methods, like enzyme-linked immunosorbent assays (ELISA) and radioactivity-linked immunosorbent assays (RIA) allow analyses of large and known proteins, mass spectrometry coupled on-line to capillary electrophoresis allows analysis of proteins and peptides of up to 20 kilodaltons (kD). Mass spectrometry allows identification and quantification of known and newly found proteins and peptides. It can also be applied to the analysis of the proteome of haematopoietic stem cells and has been shown to be able to predict acute graft-versus-host disease prior to clinical symptoms. Advances in mass spectrometry in the clinical field towards multiplexed analyses of large numbers of sample and continuous monitoring will allow for implementation into everyday clinical life.

I invite you to contribute original studies and reviews to this Special Issue, including on applications of various biomarker panels for complications after haematopoietic stem cell transplantation, analysis of the proteome of stem cells, and the role of proteomics in other pathological processes.  We are interested in receiving manuscripts describing all aspects of the current challenges in applying proteomic technologies to the development of biomarker profiles for disease, for application to clinical diagnosis. These challenges include the need for analytical rigor, reproducibility between laboratories, standardization of sample collection, storage and processing, proteomics workflows, data analysis and reporting. We are particularly interested in receiving original studies covering the discovery, measurement and clinical application of protein biomarkers and their integration with other molecular and clinical data.

I look forward to receiving your manuscripts and compiling an informative collection of pertinent articles that will serve to advance the arena of disease markers.

Prof. Dr. Eva M. Weissinger
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Clinical Proteomics
• Biomarker Discovery
• Stem cell transplantation
• Acute and chronic graft-versus-host disease
• Technical and Analytical Control Methods
• Proteomics
• Mass Spectrometry