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Micro/Nano Fluidic Devices and Bio-MEMS
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Micro/Nano Fluidic Devices and Bio-MEMS

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 May 2016) | Viewed by 54902

Special Issue Editors

Dr. Zhiping Wang

E-Mail
Guest Editor
Singapore Institute of Manufacturing Technology, 71 Nanyang Drive, Singapore
Interests: micro/nano-fluidics; microfluidics applications; printed electronics
Prof. Dr. Charles Chun Yang

E-Mail Website
Guest Editor
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Interests: microscale fluid flow and heat and mass transfer; forward osmosis for green energy generation; nanofluids based phase change heat transfer; icing, anti-icing and deicing; condensation enhancement with micro-and nano-structures; wetting and capillary flow; colloidal and interfacial phenomena

Special Issue Information

Dear Colleagues,

The field of micro/nano-fluidics devices and Bio-MEMS has been developing rapidly in the past decade. The rising demand for point-of-care diagnostics (POC), miniaturization of microfluidic devices, and the increasing applications of Bio-MEMS are leading to increasing adoption of microfluidics technology. Advancements in solute and droplet manipulations, single cell analysis, and organ-on-a-chip has had a great impact on the direction of the development of technology in the field.

The objective of this Special Issue is to collect state-of-the-art research contributions that will address the key challenges faced in the development of micro/nano-fluidics devices and Bio-MEMS. Original papers describing completed and unpublished work that are not currently under review by any other journal, magazine, or conference, are solicited.

Moreover, authors of papers submitted to the Lab-on-a-Chip Asia 2015—Microfluidics, Point of Care Diagnostics and Organ-on-a-chip, to be held in Singapore from 19–20 November 2015 (http://selectbiosciences.com/conferences/index.aspx?conf=LOACA2015) will have the opportunity to submit extended versions of their works to this Special Issue, provided that they fulfil the specific journal requirements found at https://www.mdpi.com/journal/sensors/instructions.

Topics of interests are, but not limited to:

  • Biomolecular Detection
  • Cell Separation and Capture
  • Droplet and Solute Manipulations
  • Lab-on-a-Chip
  • Microfluidics Devices
  • Organ-on-a-Chip
  • Point-of-Care Diagnostics

Dr. Zhiping Wang
Prof. Charles Chun Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • Nanofluidics
  • Bio-MEMS
  • Lab-On-a-Chip
  • Droplet
  • Organ-On-a-Chip

Published Papers (6 papers)

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Research

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6799 KiB  
Article
Design, Fabrication, Simulation and Characterization of a Novel Dual-Sided Microelectrode Array for Deep Brain Recording and Stimulation
by Zongya Zhao, Ruxue Gong, Hongen Huang and Jue Wang
Sensors 2016, 16(6), 880; https://doi.org/10.3390/s16060880 - 15 Jun 2016
Cited by 14 | Viewed by 8433
Abstract
In this paper, a novel dual-sided microelectrode array is specially designed and fabricated for a rat Parkinson’s disease (PD) model to study the mechanisms of deep brain stimulation (DBS). The fabricated microelectrode array can stimulate the subthalamic nucleus and simultaneously record electrophysiological information [...] Read more.
In this paper, a novel dual-sided microelectrode array is specially designed and fabricated for a rat Parkinson’s disease (PD) model to study the mechanisms of deep brain stimulation (DBS). The fabricated microelectrode array can stimulate the subthalamic nucleus and simultaneously record electrophysiological information from multiple nuclei of the basal ganglia system. The fabricated microelectrode array has a long shaft of 9 mm and each planar surface is equipped with three stimulating sites (diameter of 100 μm), seven electrophysiological recording sites (diameter of 20 μm) and four sites with diameter of 50 μm used for neurotransmitter measurements in future work. The performances of the fabricated microelectrode array were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry. In addition, the stimulating effects of the fabricated microelectrode were evaluated by finite element modeling (FEM). Preliminary animal experiments demonstrated that the designed microelectrode arrays can record spontaneous discharge signals from the striatum, the subthalamic nucleus and the globus pallidus interna. The designed and fabricated microelectrode arrays provide a powerful research tool for studying the mechanisms of DBS in rat PD models. Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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4225 KiB  
Article
Surface Acoustic Waves (SAW)-Based Biosensing for Quantification of Cell Growth in 2D and 3D Cultures
by Tao Wang, Ryan Green, Rajesh Ramakrishnan Nair, Mark Howell, Subhra Mohapatra, Rasim Guldiken and Shyam Sundar Mohapatra
Sensors 2015, 15(12), 32045-32055; https://doi.org/10.3390/s151229909 - 19 Dec 2015
Cited by 39 | Viewed by 11466
Abstract
Detection and quantification of cell viability and growth in two-dimensional (2D) and three-dimensional (3D) cell cultures commonly involve harvesting of cells and therefore requires a parallel set-up of several replicates for time-lapse or dose–response studies. Thus, developing a non-invasive and touch-free detection of [...] Read more.
Detection and quantification of cell viability and growth in two-dimensional (2D) and three-dimensional (3D) cell cultures commonly involve harvesting of cells and therefore requires a parallel set-up of several replicates for time-lapse or dose–response studies. Thus, developing a non-invasive and touch-free detection of cell growth in longitudinal studies of 3D tumor spheroid cultures or of stem cell regeneration remains a major unmet need. Since surface acoustic waves (SAWs) permit mass loading-based biosensing and have been touted due to their many advantages including low cost, small size and ease of assembly, we examined the potential of SAW-biosensing to detect and quantify cell growth. Herein, we demonstrate that a shear horizontal-surface acoustic waves (SH-SAW) device comprising two pairs of resonators consisting of interdigital transducers and reflecting fingers can be used to quantify mass loading by the cells in suspension as well as within a 3D cell culture platform. A 3D COMSOL model was built to simulate the mass loading response of increasing concentrations of cells in suspension in the polydimethylsiloxane (PDMS) well in order to predict the characteristics and optimize the design of the SH-SAW biosensor. The simulated relative frequency shift from the two oscillatory circuit systems (one of which functions as control) were found to be concordant to experimental data generated with RAW264.7 macrophage and A549 cancer cells. In addition, results showed that SAW measurements per se did not affect viability of cells. Further, SH-SAW biosensing was applied to A549 cells cultured on a 3D electrospun nanofiber scaffold that generate tumor spheroids (tumoroids) and the results showed the device's ability to detect changes in tumor spheroid growth over the course of eight days. Taken together, these results demonstrate the use of SH-SAW device for detection and quantification of cell growth changes over time in 2D suspension cultures and in 3D cell culture models, which may have potential applications in both longitudinal 3D cell cultures in cancer biology and in regenerative medicine. Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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4342 KiB  
Article
Centrifugal Microfluidic System for Nucleic Acid Amplification and Detection
by Baogang Miao, Niancai Peng, Lei Li, Zheng Li, Fei Hu, Zengming Zhang and Chaohui Wang
Sensors 2015, 15(11), 27954-27968; https://doi.org/10.3390/s151127954 - 04 Nov 2015
Cited by 27 | Viewed by 6960
Abstract
We report here the development of a rapid PCR microfluidic system comprising a double-shaft turntable and centrifugal-based disc that rapidly drives the PCR mixture between chambers set at different temperatures, and the bidirectional flow improved the space utilization of the disc. Three heating [...] Read more.
We report here the development of a rapid PCR microfluidic system comprising a double-shaft turntable and centrifugal-based disc that rapidly drives the PCR mixture between chambers set at different temperatures, and the bidirectional flow improved the space utilization of the disc. Three heating resistors and thermistors maintained uniform, specific temperatures for the denaturation, annealing, and extension steps of the PCR. Infrared imaging showed that there was little thermal interference between reaction chambers; the system enabled the cycle number and reaction time of each step to be independently adjusted. To validate the function and efficiency of the centrifugal microfluidic system, a 350-base pair target gene from the hepatitis B virus was amplified and quantitated by fluorescence detection. By optimizing the cycling parameters, the reaction time was reduced to 32 min as compared to 120 min for a commercial PCR machine. DNA samples with concentrations ranging from 10 to 106 copies/mL could be quantitatively analyzed using this system. This centrifugal-based microfluidic platform is a useful system and possesses industrialization potential that can be used for portable diagnostics. Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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Review

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2841 KiB  
Review
Microfluidic Surface Plasmon Resonance Sensors: From Principles to Point-of-Care Applications
by Da-Shin Wang and Shih-Kang Fan
Sensors 2016, 16(8), 1175; https://doi.org/10.3390/s16081175 - 27 Jul 2016
Cited by 108 | Viewed by 12402
Abstract
Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique. Conventional SPR sensors, which involve a planar thin gold film, have been widely exploited in biosensing; various miniaturized formats have been devised for portability purposes. Another type of SPR sensor which [...] Read more.
Surface plasmon resonance (SPR) is a label-free, highly-sensitive, and real-time sensing technique. Conventional SPR sensors, which involve a planar thin gold film, have been widely exploited in biosensing; various miniaturized formats have been devised for portability purposes. Another type of SPR sensor which utilizes localized SPR (LSPR), is based on metal nanostructures with surface plasmon modes at the structural interface. The resonance condition is sensitive to the refractive index change of the local medium. The principles of these two types of SPR sensors are reviewed and their integration with microfluidic platforms is described. Further applications of microfluidic SPR sensors to point-of-care (POC) diagnostics are discussed. Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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3314 KiB  
Review
Development of Microfluidic Systems Enabling High-Throughput Single-Cell Protein Characterization
by Beiyuan Fan, Xiufeng Li, Deyong Chen, Hongshang Peng, Junbo Wang and Jian Chen
Sensors 2016, 16(2), 232; https://doi.org/10.3390/s16020232 - 16 Feb 2016
Cited by 24 | Viewed by 8079
Abstract
This article reviews recent developments in microfluidic systems enabling high-throughput characterization of single-cell proteins. Four key perspectives of microfluidic platforms are included in this review: (1) microfluidic fluorescent flow cytometry; (2) droplet based microfluidic flow cytometry; (3) large-array micro wells (microengraving); and (4) [...] Read more.
This article reviews recent developments in microfluidic systems enabling high-throughput characterization of single-cell proteins. Four key perspectives of microfluidic platforms are included in this review: (1) microfluidic fluorescent flow cytometry; (2) droplet based microfluidic flow cytometry; (3) large-array micro wells (microengraving); and (4) large-array micro chambers (barcode microchips). We examine the advantages and limitations of each technique and discuss future research opportunities by focusing on three key performance parameters (absolute quantification, sensitivity, and throughput). Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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3034 KiB  
Review
Tunable Microfluidic Devices for Hydrodynamic Fractionation of Cells and Beads: A Review
by Jafar Alvankarian and Burhanuddin Yeop Majlis
Sensors 2015, 15(11), 29685-29701; https://doi.org/10.3390/s151129685 - 24 Nov 2015
Cited by 5 | Viewed by 6724
Abstract
The adjustable microfluidic devices that have been developed for hydrodynamic-based fractionation of beads and cells are important for fast performance tunability through interaction of mechanical properties of particles in fluid flow and mechanically flexible microstructures. In this review, the research works reported on [...] Read more.
The adjustable microfluidic devices that have been developed for hydrodynamic-based fractionation of beads and cells are important for fast performance tunability through interaction of mechanical properties of particles in fluid flow and mechanically flexible microstructures. In this review, the research works reported on fabrication and testing of the tunable elastomeric microfluidic devices for applications such as separation, filtration, isolation, and trapping of single or bulk of microbeads or cells are discussed. Such microfluidic systems for rapid performance alteration are classified in two groups of bulk deformation of microdevices using external mechanical forces, and local deformation of microstructures using flexible membrane by pneumatic pressure. The main advantage of membrane-based tunable systems has been addressed to be the high capability of integration with other microdevice components. The stretchable devices based on bulk deformation of microstructures have in common advantage of simplicity in design and fabrication process. Full article
(This article belongs to the Special Issue Micro/Nano Fluidic Devices and Bio-MEMS)
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