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Last Advances in Nanoplasmonics Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 October 2016) | Viewed by 34791

Special Issue Editor

NanoBiosensors and Bioanalytical Applications Group, Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and CIBER-BBN, Campus de la UAB, Edifici ICN2, 08193 Bellaterra (Barcelona), Spain
Interests: photonic biosensors; plasmonic and nanoplasmonic sensors; lab-on-chip devices; optonanomechanics biosensors; biofunctionalization; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plasmonics and Nanoplasmonics biosensors are the most successful optical biosensors. Continuous progress is materials, nanostructures and transducers together with advanced biofunctionalization techniques, new receptors and applications employing real samples, make them as the most studied and developed biosensors. A myriad of companies have been generated in the last few years around this powerful plamonic biosensing technology.

The aim of this Special Issue is to bring together innovative developments at the transducer schemes, nanostructures, miniaturization, biofunctionalization and applications of plasmonics and nanoplasmonics biosensors. Papers addressing the wide aspects range of this technology are sought, including but not limited to recent developments in: new transducers schemes in plasmonic and nanoplasmonics, hybrid devices, improvement of sensitivity, miniaturization and multiplexing capabilities, competitive biofunctionalization techniques, and real-life application.

Both review articles and original research papers are solicited. There is particular interest in papers concerning new applications in real life where plasmonics and nanoplasmonics could provide enhanced capabilities that cannot be obtained using other approaches.

Prof. Dr. Laura M. Lechuga
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plasmonics sensor
  • Nanoplasmonics sensor
  • Biosensors
  • Biofunctionalization techniques
  • microfluidics
  • plasmonics materials
  • point-of-care
  • medical diagnostics
  • environmental control

Published Papers (5 papers)

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Research

6481 KiB  
Article
Spectroscopic Detection of Glyphosate in Water Assisted by Laser-Ablated Silver Nanoparticles
by Rafael Eleodoro De Góes, Marcia Muller and José Luís Fabris
Sensors 2017, 17(5), 954; https://doi.org/10.3390/s17050954 - 26 Apr 2017
Cited by 21 | Viewed by 7009
Abstract
Glyphosate is one of the most widely used herbicides in the world. Its safety for both human health and aquatic biomes is a subject of wide debate. There are limits to glyphosate’s presence in bodies of water, and it is usually detected through [...] Read more.
Glyphosate is one of the most widely used herbicides in the world. Its safety for both human health and aquatic biomes is a subject of wide debate. There are limits to glyphosate’s presence in bodies of water, and it is usually detected through complex analytical procedures. In this work, the presence of glyphosate is detected directly through optical interrogation of aqueous solution. For this purpose, silver nanoparticles were produced by pulsed laser ablation in liquids. Limits of detection of 0.9 mg/L and 3.2 mg/L were obtained with UV-Vis extinction and Surface Enhanced Raman spectroscopies, respectively. The sensing mechanism was evaluated in the presence of potential interferents as well as with commercial glyphosate-based herbicides. Full article
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
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2352 KiB  
Article
Collagen-Gold Nanoparticle Conjugates for Versatile Biosensing
by Sarah Unser, Samuel Holcomb, ReJeana Cary and Laura Sagle
Sensors 2017, 17(2), 378; https://doi.org/10.3390/s17020378 - 15 Feb 2017
Cited by 25 | Viewed by 6203
Abstract
Integration of noble metal nanoparticles with proteins offers promising potential to create a wide variety of biosensors that possess both improved selectivity and versatility. The multitude of functionalities that proteins offer coupled with the unique optical properties of noble metal nanoparticles can allow [...] Read more.
Integration of noble metal nanoparticles with proteins offers promising potential to create a wide variety of biosensors that possess both improved selectivity and versatility. The multitude of functionalities that proteins offer coupled with the unique optical properties of noble metal nanoparticles can allow for the realization of simple, colorimetric sensors for a significantly larger range of targets. Herein, we integrate the structural protein collagen with 10 nm gold nanoparticles to develop a protein-nanoparticle conjugate which possess the functionality of the protein with the desired colorimetric properties of the nanoparticles. Applying the many interactions that collagen undergoes in the extracellular matrix, we are able to selectively detect both glucose and heparin with the same collagen-nanoparticle conjugate. Glucose is directly detected through the cross-linking of the collagen fibrils, which brings the attached nanoparticles into closer proximity, leading to a red-shift in the LSPR frequency. Conversely, heparin is detected through a competition assay in which heparin-gold nanoparticles are added to solution and compete with heparin in the solution for the binding sites on the collagen fibrils. The collagen-nanoparticle conjugates are shown to detect both glucose and heparin in the physiological range. Lastly, glucose is selectively detected in 50% mouse serum with the collagen-nanoparticle devices possessing a linear range of 3–25 mM, which is also within the physiologically relevant range. Full article
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
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1393 KiB  
Article
Application of the PAMONO-Sensor for Quantification of Microvesicles and Determination of Nano-Particle Size Distribution
by Victoria Shpacovitch, Irina Sidorenko, Jan Eric Lenssen, Vladimir Temchura, Frank Weichert, Heinrich Müller, Klaus Überla, Alexander Zybin, Alexander Schramm and Roland Hergenröder
Sensors 2017, 17(2), 244; https://doi.org/10.3390/s17020244 - 27 Jan 2017
Cited by 23 | Viewed by 6973
Abstract
The PAMONO-sensor (plasmon assisted microscopy of nano-objects) demonstrated an ability to detect and quantify individual viruses and virus-like particles. However, another group of biological vesicles—microvesicles (100–1000 nm)—also attracts growing interest as biomarkers of different pathologies and needs development of novel techniques for characterization. [...] Read more.
The PAMONO-sensor (plasmon assisted microscopy of nano-objects) demonstrated an ability to detect and quantify individual viruses and virus-like particles. However, another group of biological vesicles—microvesicles (100–1000 nm)—also attracts growing interest as biomarkers of different pathologies and needs development of novel techniques for characterization. This work shows the applicability of a PAMONO-sensor for selective detection of microvesicles in aquatic samples. The sensor permits comparison of relative concentrations of microvesicles between samples. We also study a possibility of repeated use of a sensor chip after elution of the microvesicle capturing layer. Moreover, we improve the detection features of the PAMONO-sensor. The detection process utilizes novel machine learning techniques on the sensor image data to estimate particle size distributions of nano-particles in polydisperse samples. Altogether, our findings expand analytical features and the application field of the PAMONO-sensor. They can also serve for a maturation of diagnostic tools based on the PAMONO-sensor platform. Full article
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
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3328 KiB  
Article
Fabrication of Annealed Gold Nanostructures on Pre-Treated Glow-Discharge Cleaned Glasses and Their Used for Localized Surface Plasmon Resonance (LSPR) and Surface Enhanced Raman Spectroscopy (SERS) Detection of Adsorbed (Bio)molecules
by Rodica Elena Ionescu, Ece Neslihan Aybeke, Eric Bourillot, Yvon Lacroute, Eric Lesniewska, Pierre-Michel Adam and Jean-Louis Bijeon
Sensors 2017, 17(2), 236; https://doi.org/10.3390/s17020236 - 26 Jan 2017
Cited by 17 | Viewed by 6425
Abstract
Metallic nanoparticles are considered as active supports in the development of specific chemical or biological biosensors. Well-organized nanoparticles can be prepared either through expensive (e.g., electron beam lithography) or inexpensive (e.g., thermal synthesis) approaches where different shapes of nanoparticles are easily obtained over [...] Read more.
Metallic nanoparticles are considered as active supports in the development of specific chemical or biological biosensors. Well-organized nanoparticles can be prepared either through expensive (e.g., electron beam lithography) or inexpensive (e.g., thermal synthesis) approaches where different shapes of nanoparticles are easily obtained over large solid surfaces. Herein, the authors propose a low-cost thermal synthesis of active plasmonic nanostructures on thin gold layers modified glass supports after 1 h holding on a hot plate (~350 °C). The resulted annealed nanoparticles proved a good reproducibility of localized surface plasmon resonance (LSPR) and surface enhanced Raman spectroscopy (SERS) optical responses and where used for the detection of low concentrations of two model (bio)chemical molecules, namely the human cytochrome b5 (Cyt-b5) and trans-1,2-bis(4-pyridyl)ethylene (BPE). Full article
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
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2058 KiB  
Article
Wavelength-Scanning SPR Imaging Sensors Based on an Acousto-Optic Tunable Filter and a White Light Laser
by Youjun Zeng, Lei Wang, Shu-Yuen Wu, Jianan He, Junle Qu, Xuejin Li, Ho-Pui Ho, Dayong Gu, Bruce Zhi Gao and Yonghong Shao
Sensors 2017, 17(1), 90; https://doi.org/10.3390/s17010090 - 05 Jan 2017
Cited by 26 | Viewed by 7498
Abstract
A fast surface plasmon resonance (SPR) imaging biosensor system based on wavelength interrogation using an acousto-optic tunable filter (AOTF) and a white light laser is presented. The system combines the merits of a wide-dynamic detection range and high sensitivity offered by the spectral [...] Read more.
A fast surface plasmon resonance (SPR) imaging biosensor system based on wavelength interrogation using an acousto-optic tunable filter (AOTF) and a white light laser is presented. The system combines the merits of a wide-dynamic detection range and high sensitivity offered by the spectral approach with multiplexed high-throughput data collection and a two-dimensional (2D) biosensor array. The key feature is the use of AOTF to realize wavelength scan from a white laser source and thus to achieve fast tracking of the SPR dip movement caused by target molecules binding to the sensor surface. Experimental results show that the system is capable of completing a SPR dip measurement within 0.35 s. To the best of our knowledge, this is the fastest time ever reported in the literature for imaging spectral interrogation. Based on a spectral window with a width of approximately 100 nm, a dynamic detection range and resolution of 4.63 × 10−2 refractive index unit (RIU) and 1.27 × 10−6 RIU achieved in a 2D-array sensor is reported here. The spectral SPR imaging sensor scheme has the capability of performing fast high-throughput detection of biomolecular interactions from 2D sensor arrays. The design has no mechanical moving parts, thus making the scheme completely solid-state. Full article
(This article belongs to the Special Issue Last Advances in Nanoplasmonics Biosensors)
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