Submit to Sensors Review for Sensors Propose a Special Issue

Journal Browser

► Journal Browser

Surface Plasmon Resonance Sensing 2019

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (20 July 2019) | Viewed by 58018

Share This Special Issue

Special Issue Editor

Prof. Dr. María Jesús Lobo-Castañón

E-Mail Website
Guest Editor

Departamento de Química Física y Analítica Universidad de Oviedo Av. Julián Clavería 8 33006 Oviedo, Spain
Interests: electrochemical biosensors; SPR sensors; aptamers; molecularly imprinted polymers; biomimetic receptors; food analysis; clinical analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Surface Plasmon Resonance (SPR) sensing platforms have been widely adopted for the real-time characterization of biomolecular interactions, such as antigen–antibody, aptamer–target or enzyme–substrate, without the use of labels. In addition, they have become useful approaches for the sensitive and label-free detection of a wide variety of molecules. Given the rapid developments in this field, Sensors is planning a Special Issue devoted to address the new developments in SPR-biosensing in terms of instrumentation, integration with nanomaterials to improve sensor performance, and approaches for miniaturization and multiplexed applications aimed at point-of-need applications.

It is my great pleasure to invite you to contribute to this Special Issue with original research or review-type articles describing most recent advances in SPR biosensor technology and their applications to the study of kinetics and thermodynamics of affinity interactions, as well as to the detection of analytes of interest in many fields, such as clinical diagnostics, food safety control and environmental monitoring.

Prof. Dr. María Jesús Lobo-Castañón
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Surface Plasmon Resonance
Chemical sensor
Biosensor
Nanotechnology
DNA
Aptamers
Antibodies
Peptides
Clinical diagnostics
Food analysis
Environmental monitoring
Multiplexed detection

Published Papers (13 papers)

Download All Papers

Research

Jump to: Other

13 pages, 5173 KiB

Open AccessArticle

Optical Fiber Cladding SPR Sensor Based on Core-Shift Welding Technology

by Yong Wei, Jiangxi Hu, Ping Wu, Yudong Su, Chunlan Liu, Shifa Wang, Xiangfei Nie and Lu Liu

Sensors 2019, 19(5), 1202; https://doi.org/10.3390/s19051202 - 09 Mar 2019

Cited by 8 | Viewed by 4528

Abstract

The typical structure of an optical fiber surface plasmon resonance (SPR) sensor, which has been widely investigated, is to produce the SPR phenomenon by the transmission of light in a fiber core. The traditional method is to peel off the fiber cladding by complex methods such as corrosion, polishing, and grinding. In this paper, the transmitted light of a single-mode fiber is injected into three kinds of fiber cladding by core-shift welding technology to obtain the evanescent field directly between the cladding and the air interface and to build the Kretschmann structure by plating with a 50-nm gold film. The SPR sensing phenomenon is realized in three kinds of fiber cladding of a single-mode fiber, a graded-index multimode fiber, and a step-index multimode fiber. For the step-index multimode fiber cladding SPR sensor, all the light field energy is coupled to the cladding, leading to no light field in the fiber core, the deepest resonance valley, and the narrowest full width at half maximum. The single-mode fiber cladding SPR sensor has the highest sensitivity, and the mean sensitivity of the probe reaches 2538 nm/RIU (refractive index unit) after parameter optimization. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

17 pages, 5691 KiB

Open AccessArticle

Limits of the Effective Medium Theory in Particle Amplified Surface Plasmon Resonance Spectroscopy Biosensors

by Jefferson S. Costa, Quaid Zaman, Karlo Q. da Costa, Victor Dmitriev, Omar Pandoli, Giselle Fontes and Tommaso Del Rosso

Sensors 2019, 19(3), 584; https://doi.org/10.3390/s19030584 - 30 Jan 2019

Cited by 14 | Viewed by 3690

Abstract

The resonant wave modes in monomodal and multimodal planar Surface Plasmon Resonance (SPR) sensors and their response to a bidimensional array of gold nanoparticles (AuNPs) are analyzed both theoretically and experimentally, to investigate the parameters that rule the correct nanoparticle counting in the emerging metal nanoparticle-amplified surface plasmon resonance (PA-SPR) spectroscopy. With numerical simulations based on the Finite Element Method (FEM), we evaluate the error performed in the determination of the surface density of nanoparticles σ when the Maxwell-Garnett effective medium theory is used for fast data processing of the SPR reflectivity curves upon nanoparticle detection. The deviation increases directly with the manifestations of non-negligible scattering cross-section of the single nanoparticle, dipole-dipole interactions between adjacent AuNPs and dipolar interactions with the metal substrate. Near field simulations show clearly the set-up of dipolar interactions when the dielectric thickness is smaller than 10 nm and confirm that the anomalous dispersion usually observed experimentally is due to the failure of the effective medium theories. Using citrate stabilized AuNPs with a nominal diameter of about 15 nm, we demonstrate experimentally that Dielectric Loaded Waveguides (DLWGs) can be used as accurate nanocounters in the range of surface density between 20 and 200 NP/µm², opening the way to the use of PA-SPR spectroscopy on systems mimicking the physiological cell membranes on SiO₂ supports. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Graphical abstract

9 pages, 2209 KiB

Open AccessArticle

The Sensitivity of Grating-Based SPR Sensors with Wavelength Interrogation

by Jianjun Cao, Yuan Sun, Yan Kong and Weiying Qian

Sensors 2019, 19(2), 405; https://doi.org/10.3390/s19020405 - 19 Jan 2019

Cited by 64 | Viewed by 6718

Abstract

In this paper, we derive the analytical expression for the sensitivity of grating-based surface plasmon resonance (SPR) sensors working in wavelength interrogation. The theoretical analysis shows that the sensitivity increases with increasing wavelength and is saturated beyond a certain wavelength for Au and Ag gratings, while it is almost constant for Al gratings in the wavelength range of 500 to 1000 nm. More importantly, the grating period (P) and the diffraction order (m) dominate the value of sensitivity. Higher sensitivity is possible for SPR sensors with a larger grating period and lower diffraction order. At long wavelengths, a simple expression of P/|m| can be used to estimate the sensor sensitivity. Moreover, we perform experimental measurements of the sensitivity of an SPR sensor based on an Al grating to confirm the theoretical calculations. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

8 pages, 1267 KiB

Open AccessArticle

An SPR Sensor Chip Based on Peptide-Modified Single-Walled Carbon Nanotubes with Enhanced Sensitivity and Selectivity in the Detection of 2,4,6-Trinitrotoluene Explosives

by Jin Wang, Sanyang Du, Takeshi Onodera, Rui Yatabe, Masayoshi Tanaka, Mina Okochi and Kiyoshi Toko

Sensors 2018, 18(12), 4461; https://doi.org/10.3390/s18124461 - 17 Dec 2018

Cited by 18 | Viewed by 6000

Abstract

In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized on a 3-aminopropyltriethoxysilane (APTES)-modified SPR Au chip surface. Through π-stacking between the aromatic amino acids and SWCNTs, the TNT recognition peptide TNTHCDR3 was immobilized onto the surface of the SWCNTs. The peptide–SWCNTs-modified sensor surface was confirmed and evaluated by atomic force microscope (AFM) observation. The peptide–SWCNTs hybrid SPR sensor chip exhibited enhanced sensitivity with a limit of detection (LOD) of 772 ppb and highly selective detection compared with commercialized carboxymethylated dextran matrix sensor chips. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

9 pages, 2540 KiB

Open AccessArticle

Fano Resonance in Waveguide Coupled Surface Exciton Polaritons: Theory and Application in Biosensor

by Jiaqi Zhu, Shuaiwen Gan, Banxian Ruan, Leiming Wu, Houzhi Cai, Xiaoyu Dai and Yuanjiang Xiang

Sensors 2018, 18(12), 4437; https://doi.org/10.3390/s18124437 - 14 Dec 2018

Cited by 3 | Viewed by 3606

Abstract

Surface exciton polaritons (SEPs) are one of the three major elementary excitations: Phonons, plasmons and excitons. They propagate along the interface of the crystal and dielectric medium. Surface exciton polaritons hold a significant position in the aspect of novel sensor and optical devices. In this article, we have realized a sharp Fano resonance (FR) by coupling the planar waveguide mode (WGM) and SEP mode with Cytop (perfluoro (1-butenyl vinyl ether)) and J-aggregate cyanine dye. After analyzing the coupling mechanism and the localized field enhancement, we then applied our structure to the imaging biosensor. It was shown that the maximum imaging sensitivity of this sensor could be as high as 5858 RIU⁻¹, which is more than three times as much as classical FR based on metal. A biosensor with ultra-high sensitivity, simple manufacturing technique and lower cost with J-aggregate cyanine dye provides us with the most appropriate substitute for the surface plasmon resonance sensors with the noble metals and paves the way for applications in new sensing technology and biological studies. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

9 pages, 2602 KiB

Open AccessArticle

Horizontal Plasmonic Ruler Based on the Scattering Far-Field Pattern

by Eunso Shin, Young Jin Lee, Youngsoo Kim and Soon-Hong Kwon

Sensors 2018, 18(10), 3365; https://doi.org/10.3390/s18103365 - 09 Oct 2018

Cited by 2 | Viewed by 2988

Abstract

A novel method is proposed to detect the horizontal shift of a specific nanoblock relative to a reference nanoblock using surface plasmon modes at nanometer resolution. To accomplish this task, two orthogonal localized surface plasmon resonances were excited within the air gap region between the silver nanoblocks at the respective wavelengths, 890 nm, and 1100 nm. This technique utilized the scattering far-field intensities of the two block nanostructures at the two specific wavelengths at two specific directional spots. The ratio of the scattering intensities at the two spots changed according to the horizontal shift of the block that moved. Correspondingly, this ratio can be used to provide the precise location of the block. This method can be applied to many fields, including label-free bio-sensing, bio-analysis and alignment during nano-fabrication, owing to the high resolution and simplicity of the process. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

11 pages, 2862 KiB

Open AccessArticle

Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence

by Kaiwei Li, Wenchao Zhou and Shuwen Zeng

Sensors 2018, 18(10), 3295; https://doi.org/10.3390/s18103295 - 30 Sep 2018

Cited by 34 | Viewed by 5644

Abstract

Integration of functional nanomaterials with optical micro/nanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diameter by taking micro/nanofiber-based localized surface plasmon resonance sensors as a model. We systematically study the dependence of fiber diameter on the sensing performance of such sensors. Both theoretical and experimental results show that, by reducing fiber diameter, the refractive index sensitivity can be significantly increased. Then, we demonstrate the biosensing capability of the optimized sensor for streptavidin detection and achieve a detection limit of 1 pg/mL. Furthermore, the proposed theoretical model is applicable to other nanomaterials and OMNF-based sensing schemes for performance optimization. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

17 pages, 3039 KiB

Open AccessArticle

Implementing Morpholino-Based Nucleic Acid Sensing on a Portable Surface Plasmon Resonance Instrument for Future Application in Environmental Monitoring

by Andrea Bagi, Scott D. Soelberg, Clement E. Furlong and Thierry Baussant

Sensors 2018, 18(10), 3259; https://doi.org/10.3390/s18103259 - 28 Sep 2018

Cited by 8 | Viewed by 4270

Abstract

A portable surface plasmon resonance (SPR) instrument was tested for the first time for the detection of oligonucleotide sequences derived from the 16S rRNA gene of Oleispira antarctica RB-8, a bioindicator species of marine oil contamination, using morpholino-functionalized sensor surfaces. We evaluated the stability and specificity of morpholino coated sensor surfaces and tested two signal amplification regimes: (1) sequential injection of sample followed by magnetic bead amplifier and (2) a single injection of magnetic bead captured oligo. We found that the sensor surfaces could be regenerated for at least 85 consecutive sample injections without significant loss of signal intensity. Regarding specificity, the assay clearly differentiated analytes with only one or two mismatches. Signal intensities of mismatch oligos were lower than the exact match target at identical concentrations down to 200 nM, in standard phosphate buffered saline with 0.1 % Tween-20 added. Signal amplification was achieved with both strategies; however, significantly higher response was observed with the sequential approach (up to 16-fold), where first the binding of biotin-probe-labeled target oligo took place on the sensor surface, followed by the binding of the streptavidin magnetic beads onto the immobilized targets. Our experiments so far indicate that a simple coating procedure in combination with a relatively cost-efficient magnetic-bead-based signal amplification will provide robust SPR based nucleic acid sensing down to 0.5 nM of a 45-nucleotide long oligo target (7.2 ng/mL). Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

12 pages, 3194 KiB

Open AccessArticle

Surface-Plasmon-Resonance-Based Optical-Fiber Micro-Displacement Sensor with Temperature Compensation

by Yong Wei, Ping Wu, Zongda Zhu, Lu Liu, Chunlan Liu, Jiangxi Hu, Shifa Wang and Yonghui Zhang

Sensors 2018, 18(10), 3210; https://doi.org/10.3390/s18103210 - 23 Sep 2018

Cited by 17 | Viewed by 3426

Abstract

Micro-displacement measurements play a crucial role in many industrial applications. Aiming to address the defects of existing optical-fiber displacement sensors, such as low sensitivity and temperature interference, we propose and demonstrate a novel surface plasmon resonance (SPR)-based optical-fiber micro-displacement sensor with temperature compensation. The sensor consists of a displacement-sensing region (DSR) and a temperature-sensing region (TSR). We employed a graded-index multimode fiber (GI-MMF) to fabricate the DSR and a hetero-core structure fiber to fabricate the TSR. For the DSR, we employed a single-mode fiber (SMF) to change the radial position of the incident beam as displacement. The resonance angle in the DSR is highly sensitive to displacement; thus, the resonance wavelength of the DSR shifts. For the TSR, we employed polydimethylsiloxane (PDMS) as a temperature-sensitive medium, whose refractive index is highly sensitive to temperature; thus, the resonance wavelength of the TSR shifts. The displacement and temperature detection ranges are 0–25 μm and 20–60 °C; the displacement and temperature sensitivities of the DSR are 4.24 nm/μm and −0.19 nm/°C, and those of the TSR are 0.46 nm/μm and −2.485 nm/°C, respectively. Finally, by means of a sensing matrix, the temperature compensation was realized. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

19 pages, 6892 KiB

Open AccessArticle

Quantitative Cross-Platform Performance Comparison between Different Detection Mechanisms in Surface Plasmon Sensors for Voltage Sensing

by Phitsini Suvarnaphaet and Suejit Pechprasarn

Sensors 2018, 18(9), 3136; https://doi.org/10.3390/s18093136 - 17 Sep 2018

Cited by 12 | Viewed by 2999

Abstract

Surface plasmon Resonance (SPR) has recently been of interest for label-free voltage sensing. Several SPR structures have been proposed. However, making a quantitative cross-platform comparison for these structures is not straightforward due to (1) different SPR measurement mechanisms; (2) different electrolytic solution and concentration in the measurement; and (3) different levels of external applied potential. Here, we propose a quantitative approach to make a direct quantitative comparison across different SPR structures, different electrolytic solutions and different SPR measurement mechanisms. There are two structures employed as example in this theoretical study including uniform plasmonic gold sensor and bimetallic layered structure consisting of uniform silver layer (Ag) coated by uniform gold layer (Ag). The cross-platform comparison was carried by several performance parameters including sensitivity (S), full width half maximum (FWHM) and figure of merit (FoM). We also discuss how the SPR measurement mechanisms enhance the performance parameters and how the bimetallic layer can be employed to enhance the FoM by a factor of 1.34 to 25 depending on the SPR detection mechanism. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

17 pages, 6385 KiB

Open AccessArticle

Enhancement of Long-Range Surface Plasmon Excitation, Dynamic Range and Figure of Merit Using a Dielectric Resonant Cavity

by Phitsini Suvarnaphaet and Suejit Pechprasarn

Sensors 2018, 18(9), 2757; https://doi.org/10.3390/s18092757 - 22 Aug 2018

Cited by 18 | Viewed by 4691

Abstract

In this paper, we report a theoretical framework on the effect of multiple resonances inside the dielectric cavity of insulator-insulator-metal-insulator (IIMI)-based surface plasmon sensors. It has been very well established that the structure can support both long-range surface plasmon polaritons (LRSPP) and short-range surface plasmon polaritons (SRSPP). We found that the dielectric resonant cavity under certain conditions can be employed as a resonator to enhance the LRSPP properties. These conditions are: (1) the refractive index of the resonant cavity was greater than the refractive index of the sample layer and (2) when light propagated in the resonant cavity and was evanescent in the sample layer. We showed through the analytical calculation using Fresnel equations and rigorous coupled wave theory that the proposed structure with the mentioned conditions can extend the dynamic range of LRSPP excitation and enhance at least five times more plasmon intensity on the surface of the metal compared to the surface plasmon excited by the conventional Kretschmann configuration. It can enhance the dip sensitivity and the dynamic range in refractive index sensing without losing the sharpness of the LRSPP dip. We also showed that the interferometric modes in the cavity can be insensitive to the surface plasmon modes. This allowed a self-referenced surface plasmon resonance structure, in which the interferometric mode measured changes in the sensor structure and the enhanced LRSPP measured changes in the sample channel. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

12 pages, 2943 KiB

Open AccessArticle

Surface-Plasmon-Resonance-Based Optical Fiber Curvature Sensor with Temperature Compensation by Means of Dual Modulation Method

by Yudong Su, Yong Wei, Yonghui Zhang, Chunlan Liu, Xiangfei Nie, Zongda Zhu and Lu Liu

Sensors 2018, 18(8), 2608; https://doi.org/10.3390/s18082608 - 09 Aug 2018

Cited by 35 | Viewed by 4992

Abstract

Curvature measurement plays an important role in many fields. Aiming to overcome shortcomings of the existing optical fiber curvature sensors, such as complicated structure and difficulty in eliminating temperature noise, we proposed and demonstrated a simple optical fiber curvature sensor based on surface plasmon resonance. By etching cladding of the step-index multimode fiber and plating gold film on the bare core, the typical Kretschmann configuration is implemented on fiber, which is used as the bending-sensitive region. With increases in the curvature of the optical fiber, the resonance wavelength of the SPR (Surface Plasmon Resonance) dip linear red-shifts while the transmittance decreases linearly. In the curvature range between 0 and 9.17 m⁻¹, the wavelength sensitivity reached 1.50 nm/m⁻¹ and the intensity sensitivity reached −3.66%/m⁻¹. In addition, with increases in the ambient temperature, the resonance wavelength of the SPR dips linearly blueshifts while the transmittance increases linearly. In the temperature range between 20 and 60 °C, the wavelength sensitivity is −0.255 nm/°C and the intensity sensitivity is 0.099%/°C. The sensing matrix is built up by combining the aforementioned four sensitivities. By means of the dual modulation method, the cross-interference caused by temperature change is eliminated. Additionally, simultaneous measurement of curvature and temperature is realized. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

Other

Jump to: Research

10 pages, 2355 KiB

Open AccessLetter

A Polarization-Independent Fiber-Optic SPR Sensor

by Songquan Li, Laixu Gao, Changwei Zou, Wei Xie, Yong Wei, Canxin Tian, Zesong Wang, Feng Liang, Yanxiong Xiang and Qian Yang

Sensors 2018, 18(10), 3204; https://doi.org/10.3390/s18103204 - 22 Sep 2018

Cited by 10 | Viewed by 3610

Abstract

Fiber-optic surface plasmon resonance (SPR) sensors possess the advantages of small size, flexible, allowing for a smaller sample volume, easy to be integrated, and high sensitivity. They have been intensively developed in recent decades. However, the polarizing nature of the surface plasmon waves (SPWs) always hinders the acquisition of SPR spectrum with high signal-noise ratio in wavelength modulation unless a polarizer is employed. The addition of polarizer complicates the system and reduces the degree of compactness. In this work, we propose and demonstrate a novel, polarization-independent fiber-optic SPR sensor based on a BK7 bi-prism with two incident planes orthogonal to each other. In the bi-prism, TM-polarized components of non-polarized incident lights excite SPWs on the first sensing channel, meanwhile the TE components and the remaining TM components are reflected, then the reflected TE components serve as TM components of incident lights for the second sensing channel to excite SPWs. Simulations show the proposed SPR structure permit us to completely eliminate the polarization dependence of the plasmon excitation. Experimental results agree well with the simulations. This kind of devices can be considered an excellent option for development of simple and compact SPR chemical sensors. Full article

(This article belongs to the Special Issue Surface Plasmon Resonance Sensing 2019)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Surface Plasmon Resonance Sensing 2019

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (13 papers)

Research

Other

Further Information

Guidelines

MDPI Initiatives

Follow MDPI