Special Issue "Sensors and Biosensors Using Label Free Chemistries"
A special issue of Sensors (ISSN 1424-8220).
Deadline for manuscript submissions: closed (15 January 2012)
Prof. Dr. Séamus P.J. Higson (Website)
Cranfield Health, Cranfield University, Cranfield, MK43 0AL, UK
Interests: electrochemical biosensors; biosensors for healthcare; biosensors for environmental monitoring; DNA sensors; enzymatic sensors; affinity based biosensors; antibody based biosensors; micro-electrodes and micro-electrode arrays
Sensors, biosensors and the wider field of biological test kits/assays has continued to be an area of active and indeed rapidly expanding research during the past two decades with many new commercial tests having been successfully brought to the market. Many of these have exploited the specificity afforded by the use of biological chemistries and while these have allowed full commercialisation of devices for routine use, the coupling of this chemistry to a transducer (or other detection means) to allow readings to be taken, has often required the use of some form of chemical or radio-label. One of most obvious examples of this can be seen in the widespread use of Enzyme-Linked-Immuno-Sorbent-Assays or ELISA based chemistries. The development and manufacture of these tests often involves the use of relatively complicated covalent (and other) coupling chemistries and the tests do not always lend themselves to quantitative analyses but rather have found greatest application in situations where qualitative, positive or negative answers suffice (e.g., to detect the presence or absence of infection).
One of the most recent research trends has been to try to simplify the chemistries within biological assays and biosensors often by using chemistries that do not require the use of a label. These approaches offer promise for greater ease of use and in some cases may facilitate quantitative determinations.
This special edition will consider some of the promising research along with those approaches that have already become accepted. Since this is a rapidly developing area that is attracting considerable interest within the research community and beyond, consideration is also being given to possible future trends and potential application areas ranging from medicine through to environmental monitoring and home-land security.
Prof. Dr. Séamus P.J. Higson
- labeless sensors
- labeless chemistries for sensors
- affinity sensors
- labeless antibody
- labeless nucleic acid
- labeless DNA
- labeless RNA
- laleess apatamers
- synthetic receptors