Special Issue "Chiral Separations"
A special issue of Symmetry (ISSN 2073-8994).
Deadline for manuscript submissions: closed (30 June 2017)
Prof. Dr. Maria Elizabeth Tiritan
1. Institute of Research and Advanced Training in Health Sciences and Technologies, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
2. Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
3. Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, Portugal Email: firstname.lastname@example.org
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Interests: drug discovery; chiral bioactive compounds; enantiomeric separation; chiral stationary phases and chiral analyses
The importance of chiral separation has been known since Louis Pasteur verified that (-)-tartaric acid was not being metabolized, or was being metabolized much slower than (+)-tartaric acid by Penicillium glaucum in the wine-fermentation process. A few years later, Emile Fischer observed the consequence of the enzymes in selective metabolism by microorganisms, after analyzing the crude extracts of yeast and a preparation obtained from almonds, he found out that only one of the isomers of the monosaccharide methylglucoside was present in each solution. By the same time, in 1886, the Italian chemist Arnaldo Piutti found that D-asparagine was responsible for the sweet taste while L-asparagine was tasteless. Nowadays, the influence of chirality in biological systems is an established fact that should always be kept in mind in the design of new drugs, pesticides, food additives and even fragrances. The biological response of each enantiomer must always be evaluated before its commercialization. Given the verified importance of chirality in the biological systems, the separation of enantiomers is of crucial importance in analytical (quality control) and in the preparative methods to obtain pure enantiomers. Accordingly, the aim of this Special Issue, “Chiral Separations”, is to reunite the different tools regarding separation of enantiomers in preparative and analytical mode. It is important to present not only the results from well establish methodologies such as chiral chromatography but to highlight innovations within chiral separations. Contributions which address innovations in selective liquid–liquid extraction, membrane separation, crystallization, kinetic or dynamic kinetic resolution, chromatography, and capillary electrophoresis are cordially invited.
Prof. Dr. Maria Elizabeth Tiritan
Manuscript Submission Information
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- Chiral chromatography
- Enantioselective liquid–liquid extraction
- Chiral Capillary Electrophoresis
- Kinetic resolution
- Enantiomeric purity