Dear Colleagues,

Neurodegenerative diseases are a major public health concern because of the debilitating symptoms and rising incidence for these diseases that are age-dependent. Cases directly attributable to inheritance comprise a small percentage of the overall affected population. Given that curative treatments are not available, and that translation from animal models to clinical trials has been quite poor, the identification and mitigation of modifiable risk factors is critical to impact disease incidence. Of note, decades of research have implicated environmental factors in the etiology of multiple neurodegenerative diseases. More recently, specific factors, including individual gene-environment interactions are being identified in the basic laboratory and epidemiological studies. Pesticides and occupational exposures to heavy metals, solvents, and other compounds have received much attention. Diet represents a potentially widespread and modifiable exposure.

The focus of this Special Issue in Toxics entitled, “Dietary Toxicants and Neurological Disease” is on how toxicants in the diet may influence the etiology of major neurodegenerative diseases. While the focus is on diseases of significant public health concern and environmentally-linked etiologies, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, any studies related to dietary toxicants and neurodegeneration will be considered. Basic science, epidemiological, policy-based, and review submissions are encouraged. In considering the exposure: Food contaminants, compounds formed during preparation, or diets deficient or in excess of certain nutrients are all deemed to be relevant to this Special Issue. It is hoped that this Special Issue will raise scientific and public awareness on the potential role of dietary exposures in the etiology of neurological diseases and advance the field.

Prof. Dr. Jason Cannon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• neurodegeneration
• neurotoxicity
• diet
• Alzheimer’s disease
• Parkinson’s disease
• amyotrophic lateral sclerosis