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Special Issue "Heat-Stable Enterotoxins"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 15 August 2017

Special Issue Editor

Guest Editor
Prof. Dr. Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Website | E-Mail
Interests: guanylate cyclase C in health and disease

Special Issue Information

Dear Colleagues,

Diarrheagenic bacterial heat-stable enteroxins (STs) are a major cause of morbidity and mortality worldwide. This family of homologous toxins induces diarrhea by recapitulating the structure of the endogenous intestinal paracrine hormones guanylin and uroguanylin. This molecular mimicry confers on STs the ability to co-opt signaling through the intestinal receptor guanylate cyclase C (GCC), which regulates epithelial fluid and electrolyte balance. Beyond secretion, GCC and its cognate ligands have emerged as important regulators of fundamental homeostatic processes which organize the intestinal crypt-surface axis. Moroever, dysregulation of this signaling system plays a key role in pathophysiological processes beyond infectious diarrhea, including intestinal transformation, mucosal inflammation, and gut–brain satiety signaling. Understanding the normal function of the GCC signaling axis, and mechanisms underlying its pathophysiological disruption, provides unique opportunities to create therapeutic solutions using toxins and their cognate receptors for major diseases including infectious diarrhea, chronic constipation, colorectal cancer, inflammatory bowel disease and obesity.

Prof. Dr. Scott A. Waldman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • heat-stable enterotoxins;
  • guanylate cyclase C;
  • guanylin;
  • uroguanylin;
  • secretory diarrhea;
  • chronic constipation;
  • colorectal cancer;
  • irritable bowel syndrome (constipation type);
  • inflammatory bowel disease;
  • obesity

Published Papers

This special issue is now open for submission.

Journal Contact

Toxins Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
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