Role of Autophagy in Viral Infection
A topical collection in Cells (ISSN 2073-4409). This collection belongs to the section "Autophagy".
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Topical Collection Information
Dear Colleagues,
Macroautophagy (hereafter referred to as autophagy) is a degradation pathway whereby cytosolic double-membrane-bound compartments termed autophagosomes engulf cytoplasmic constituents such as sub-cellular organelles and microbial pathogens, and target them for lysosomal degradation. Autophagy is thus an autonomous innate immune defense through which cells can eliminate viruses by capture into autophagosomes with subsequent killing through autophagy. Autophagy can also restrict viral infection by promoting the survival or death of infected cells, control inflammation by cooperating with pattern recognition receptor signaling to induce pro- and anti-inflammatory cytokines, and coordinate adaptive immunity by delivering virus-derived antigens for presentation to CD4+ and CD8+ T cells. However, viruses can also usurp autophagy to promote their propagation. Examples of the latter include membrane rearrangements, direct antagonism of autophagy proteins, and the prevention of autolysosome maturation.
In this Collection of Cells, I invite you to contribute papers in the form of original research articles, reviews, or shorter perspective articles, on all aspects related to the theme of “Role of Autophagy in Viral Infections”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of the interplay between autophagy and specific viruses (or viruses within a single family) of medical and veterinary importance, as well as future therapeutics using autophagy to control viral infections, are highly welcome.
Dr. Grant R. Campbell
Collection Editor
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Keywords
- animal viruses
- autophagy
- human viruses
- immunity
- inflammation
- non-lytic release
- secretory autophagy
- translational medicine
- viral evasion
- viral pathogenesis
- virophagy
- virus
- virus–host interactions
- xenophagy