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Gut Microbiome and Its Impact on Human Health
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Gut Microbiome and Its Impact on Human Health

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Disease Biomarker".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 2404

Special Issue Editors

Dr. Qing Ai

E-Mail Website
Guest Editor
Research Diets, Inc., New Brunswick, NJ 08201, USA
Interests: gut microbiome; diabetes; obesity; probiotics; fibers; IBD
Dr. Joanna B. Bierła

E-Mail Website
Guest Editor
Department of Pathomorphology, Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland
Interests: celiac disease; Crohn’s disease; α-1 anti-trypsin deficiency; Wilson’s disease; food allergies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gut microbiome has emerged as a dynamic field of study with profound implications for human health. Over the past decade, research has shown the complex interplay between the gut microbiome and various aspects of human health, including nutrition, immune function, metabolism, physiology, and even mental health.

The current Special Issue aims to provide a comprehensive overview of the current state of research on the gut microbiome and its implications for human health. We intend to explore the intricate mechanisms governing the gut microbiome–host interactions and their role in both health and disease. Furthermore, we aim to highlight the potential therapeutic applications and both the preclinical and clinical relevance of this knowledge.

This Special Issue will feature cutting-edge research articles, reviews, and perspectives from leading experts in the field. Thus, we welcome diverse contributions, including original research articles, systematic reviews, and meta-analyses related to the gut microbiome and its effects on human health. Topics of interest include, but are not limited to, microbiome-based therapies, personalized medicine approaches, and the role of diet and lifestyle in shaping the gut microbiome.

We look forward to your contributions.

Dr. Qing Ai
Dr. Joanna B. Bierła
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • diet and microbiome
  • probiotics
  • gut–brain axis
  • microbiome therapies
  • microbiome modulation
  • inflammatory bowel disease

Published Papers (2 papers)

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Review

18 pages, 1020 KiB  
Review
Exploring the Gut Microbiome’s Role in Inflammatory Bowel Disease: Insights and Interventions
by Despoina Gyriki, Christos Nikolaidis, Elisavet Stavropoulou, Ioanna Bezirtzoglou, Christina Tsigalou, Stergios Vradelis and Eugenia Bezirtzoglou
J. Pers. Med. 2024, 14(5), 507; https://doi.org/10.3390/jpm14050507 - 11 May 2024
Viewed by 696
Abstract
Inflammatory Bowel Disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition of the intestine that significantly impairs quality of life and imposes a heavy burden on healthcare systems globally. While the exact etiology of IBD [...] Read more.
Inflammatory Bowel Disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition of the intestine that significantly impairs quality of life and imposes a heavy burden on healthcare systems globally. While the exact etiology of IBD is unclear, it is influenced by genetic, environmental, immunological, and microbial factors. Recent advances highlight the gut microbiome’s pivotal role in IBD pathogenesis. The microbial dysbiosis characteristic of IBD, marked by a decline in beneficial bacteria and an increase in pathogenic microbes, suggests a profound connection between microbial imbalance and disease mechanisms. This review explores diagnostic approaches to IBD that integrate clinical assessment with advanced microbiological analyses, highlighting the potential of microbiome profiling as a non-invasive diagnostic tool. In addition, it evaluates conventional and emerging treatments and discusses microbiome-targeted intervention prospects, such as probiotics, symbiotics, and faecal microbiota transplantation. The necessity for future research to establish their efficacy and safety is emphasised. Full article
(This article belongs to the Special Issue Gut Microbiome and Its Impact on Human Health)
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12 pages, 995 KiB  
Review
The Role of Methanogenic Archaea in Inflammatory Bowel Disease—A Review
by Agata Anna Cisek, Edyta Szymańska, Tamara Aleksandrzak-Piekarczyk and Bożena Cukrowska
J. Pers. Med. 2024, 14(2), 196; https://doi.org/10.3390/jpm14020196 - 10 Feb 2024
Viewed by 1233
Abstract
Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike [...] Read more.
Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children. Full article
(This article belongs to the Special Issue Gut Microbiome and Its Impact on Human Health)
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