Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Round 1

Reviewer 1 Report

The manuscript entitled "BioArchitecture design principles for bioactive biopolymers: Harnessing the structure-function paradigm for diabetic wound healing" has been well-organized and well-defined. However some minor concerns should be addressed before acceptance.

1. Section 2 .1, 2.2, 2.3 & 2.4 require conclusion for consequence of bioploymers in chronic wounds. 

2. for chitosan and alginate, the abbreviation should be provided for better presentation. 

3. nanofiber-based wound dressings for chronic wounds should be provided for main sections.

4. limitation should be provided for section 3. 

 Minor editing of English language required

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

Generally, the review is well structured and the informations are of interest for researches in this field, but some observations are necessary:

Line 125 – „Structure – function paradigme as shown in equation 2...”- In Figure 1 equation 2 is mentioned, but it is not written anywhere in the text. It may be about equation 1?

In the text, reference numbers should be placed in square brackets (instructions for authors), but a few situation require correction. For example:

Line 131 - [26], [28] correction [26, 28]

Line 133 - [29], [30] correction [29, 30].

Line 149, 159,

Line 188 [40], [38] correction [38, 40] and so on. Please, revise throughout the text.

English revision is needed.

Author Response

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Author Response File: Author Response.docx

Reviewer 3 Report

See attached file

Comments for author File: Comments.pdf

English used is correct and readable

Author Response

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Author Response File: Author Response.docx

Round 2

Reviewer 3 Report

The authors responded to all my comments and improved the manuscript, which can now be recommended for publication.