Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum
Abstract
:Introduction
Results and Discussion
Structure Elucidation
Position | 1 | 2 | ||
---|---|---|---|---|
C | H (J, Hz) | C | H (J Hz) | |
1 | 45.8 | 2.48, d, (7.0) | 44.6 | 2.41, d, (7.2) |
2.87, d, (7.9) | 2.85, d, (7.6) | |||
2 | 69.2 | 4.78, m | 70.8 | 4.78, m |
3 | 87.8 | 4.68, m | 82.8 | 4.32, m |
4 | 48.4 | 43.2 | ||
5 | 46.1 | 0.92, dd, (6.6, 7.0) | 47.9 | 0.83, dd, (6.4, 6.9) |
6 | 18.9 | 17.4 | ||
7 | 35.3 | 35.0 | ||
8 | 42.8 | 42.8 | ||
9 | 45.3 | 2.20, dd, (7.2, 7.8) | 45.1 | 2.22, dd, (7.3, 8.0) |
10 | 37.5 | 36.7 | ||
11 | 30.5 | 1.84, m | 30.2 | 1.87, m |
2.37, m | 2.40, m | |||
12 | 66.1 | 4.54, m | 66.2 | 4.46, m |
13 | 92.8 | 92.6 | ||
14 | 43.3 | 43.1 | ||
15 | 39.8 | 2.43, m | 39.8 | 2.37, m |
16 | 72.7 | 4.51, m | 72.7 | 4.43, m |
17 | 49.1 | 49.0 | ||
18 | 53.3 | 53.2 | ||
19 | 40.8 | 40.7 | ||
20 | 32.0 | 31.9 | ||
21 | 35.8 | 2.54, dd, (7.0, 7.6) | 35.7 | 2.48, dd, (7.0, 7.5) |
22 | 29.0 | 2.07, dd, (7.0, 15.5) | 29.0 | 2.02, dd, (7.0, 15.0) |
2.26, dd, (7.6, 15.5) | 2.30, dd, (7.5, 15.0) | |||
23 | 63.3 | 4.30, m | 65.0 | 4.10, m |
4.86, m | 4.52, m | |||
24 | 66.1 | 4.24, m | 14.9 | 1.31, s |
4.75, m | ||||
25 | 20.2 | 1.52, s | 18.8 | 1.51, s |
26 | 18.4 | 1.34, s | 18.5 | 1.30, s |
27 | 21.0 | 1.94, s | 21.1 | 1.89, s |
28 | 178.1 | 178.1 | ||
29 | 33.4 | 1.09, s | 33.4 | 1.01, s |
30 | 24.6 | 1.09, s | 24.5 | 1.01, s |
1′ | 106.5 | 5.14, d, (7.7) | 105.6 | 5.14, d, (7.0) |
2′ | 75.4 | 3.80 | 75.3 | 3.82 |
3′ | 78.9 | 4.05 | 88.8 | 3.93 |
4′ | 71.8 | 3.96 | 69.7 | 3.97 |
5′ | 78.9 | 3.87 | 77.9 | 3.86 |
6′ | 62.7 | 4.04, 4.18 | 62.6 | 4.05, 4.19 |
1″ | 106.0 | 5.22, d, (6.6) | ||
2″ | 75.6 | 3.77 | ||
3″ | 78.8 | 4.02 | ||
4″ | 71.7 | 3.94 | ||
5″ | 78.3 | 3.85 | ||
6″ | 62.3 | 3.99, 4.15 |
Cytotoxic activity
Conclusions
Experimental
General
Plant Material
Extraction and Isolation
Acid Hydrolysis
Cytotoxicity Assays
Acknowledgments
References
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Zhang, L.; Liu, Z.-H.; Tian, J.-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules 2007, 12, 832-841. https://doi.org/10.3390/12040832
Zhang L, Liu Z-H, Tian J-K. Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum. Molecules. 2007; 12(4):832-841. https://doi.org/10.3390/12040832
Chicago/Turabian StyleZhang, Lin, Zhen-Huan Liu, and Jing-Kui Tian. 2007. "Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum" Molecules 12, no. 4: 832-841. https://doi.org/10.3390/12040832