Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne
Abstract
:1. Introduction
2. Results and Discussion
No. | 1 | 5 | ||
---|---|---|---|---|
δH | δC | δH | δC | |
1β | 2.02 dd (12.4, 11.8) | 49.3 | 7.57 s | 161.0 |
2α | 1.57 m | 37.9 | 133.1 | |
3α | 3.79 d (2.0) | 79.5 | 209.1 | |
4 | 78.9 | 74.0 | ||
5α | 3.73 br s | 71.0 | 2.53 d (19.0) | 38.9 |
5β | 2.46 d (19.0) | |||
6 | 60.2 | 140.7 | ||
7β | 3.30 s | 64.4 | 5.66 d (4.5) | 129.5 |
8β | 3.01 d (2.4) | 37.0 | 3.22 dd (4.5, 5.1) | 39.3 |
9 | 81.4 | 78.4 | ||
10α | 2.77 d (12.4) | 48.8 | 3.23 s | 56.4 |
11 | 2.36 m | 35.8 | 2.15 m overlap | 43.4 |
12a12b | 2.17 dd (8.4, 13.9) 1.66 d (13.9) | 36.6 | 5.44 d (10.3) | 76.8 |
13 | 84.1 | 66.0 | ||
14 | 4.23 d (2.4) | 82.1 | 1.08 d (5.1) | 36.6 |
15 | 147.0 | 26.0 | ||
16a16b | 4.97 s4.86 s | 111.2 | 1.24s | 17.0 |
17 | 1.75 s | 19.1 | 1.19 s | 24.0 |
18 | 1.25 d (7.0) | 21.3 | 0.87 d (6.6) | 14.6 |
19 | 1.04 d (6.6) | 14.8 | 1.75 d (1.5) | 10.3 |
20a20b | 4.93 d (11.9) 3.90 d (11.9) | 68.1 | 4.02 d (13.0)3.97 d (13.0) | 68.3 |
1′ | 120.0 | 167.3 | ||
2′ | 1.89 m | 33.9 | 5.76 d (15.4) | 119.1 |
3′ | 1.53 m1.66 m | 19.7 | 7.21 dd (15.4, 9.8) | 145.8 |
4′ | 1.22 m | 27.8 | 6.16 dd (9.8, 15.2) | 128.5 |
5′ | 1.23 m | 24.2 | 6.13 m | 145.5 |
6′ | 1.30 m | 24.7 | 2.13 m overlap | 33.2 |
7′ | 1.53 m1.39 m | 24.3 | 1.41 m | 28.6 |
8′ | 1.30 m0.94 m | 24.5 | 1.28 m | 31.6 |
9′ | 2.32 m | 27.3 | 1.28 m | 22.7 |
10′ | 0.89 d (7.3) | 19.1 | 0.86 t (6.9) | 14.2 |
1′′ | 167.3 | 174.0 | ||
2′′ | 6.52 d (16.0) | 117.9 | 2.08 s | 21.3 |
3′′ | 7.72 d (16.0) | 145.8 | ||
4′′ | 134.6 | |||
5′′ | 7.52 m | 128.4 | ||
6′′ | 7.37 m | 129.1 | ||
7′′ | 7.37 m | 130.7 | ||
8′′ | 7.37 m | 129.1 | ||
9′′ | 7.52 m | 128.4 |
Compounds | HL-60 | SMMC-7721 | A-549 | MCF-7 | SW480 | BEAS-2B |
---|---|---|---|---|---|---|
1 | 26.43 | >40 | >40 | >40 | >40 | >40 |
2 | 13.81 | 17.51 | 12.06 | 12.78 | 15.93 | 17.35 |
3 | 13.29 | 14.93 | 11.10 | 13.98 | 14.44 | 15.43 |
4 | 15.57 | 18.09 | 12.57 | 15.97 | 13.30 | 17.38 |
5 | 15.79 | 15.12 | 15.75 | 14.96 | 14.79 | 16.55 |
6 | >40 | >40 | >40 | >40 | >40 | >40 |
7 | >40 | >40 | >40 | >40 | >40 | >40 |
8 | >40 | >40 | >40 | >40 | >40 | >40 |
9 | >40 | >40 | >40 | >40 | >40 | >40 |
10 | >40 | >40 | >40 | >40 | >40 | >40 |
DDP ( cis-platin) | 1.25 | 16.18 | 14.05 | 16.95 | 18.05 | 8.61 |
Taxol | <0.008 | <0.008 | <0.008 | <0.008 | <0.008 | 5.00 |
3. Experimental
3.1. General Procedures
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Cytotoxicity Assays
4. Conclusions
Acknowledgments
References and Notes
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Guo, J.; Zhang, J.; Shu, P.; Kong, L.; Hao, X.; Xue, Y.; Luo, Z.; Li, Y.; Li, G.; Yao, G.; et al. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17, 6424-6433. https://doi.org/10.3390/molecules17066424
Guo J, Zhang J, Shu P, Kong L, Hao X, Xue Y, Luo Z, Li Y, Li G, Yao G, et al. Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules. 2012; 17(6):6424-6433. https://doi.org/10.3390/molecules17066424
Chicago/Turabian StyleGuo, Jieru, Jinwen Zhang, Penghua Shu, Lingmei Kong, Xincai Hao, Yongbo Xue, Zengwei Luo, Yan Li, Gao Li, Guangmin Yao, and et al. 2012. "Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne" Molecules 17, no. 6: 6424-6433. https://doi.org/10.3390/molecules17066424