Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General and Instruments
3.2. Synthesis
3.3. Microbial Strains and Growth Conditions
3.4. Determination of Minimal Inhibitory Concentration
3.5. Cell Line and Culture
3.6. Cytotoxicity Assays
4. Conclusions
Supplementary Materials
Acknowledgments
References
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Sample Availability: Samples of the compound [BiCl3(C11H11N3O2S)3] are available from the authors. |
Empirical formula | C33H33BiCl3N9O6S3 |
---|---|
Formula weight | 1063.22 |
Temperature | 293(2) K |
Wavelength | 0.71073 Å |
Crystal system | Trigonal |
Space group | R 3 |
Unit cell dimensions | a = 17.9557(3), b = 17.9557(3), c = 10.19691 (12) Å, α = 90, β = 90, γ = 120° |
Volume | 2847.12(7) Å3 |
Z | 3 |
Density (calculated) | 1.860 Mg/m3 |
Absorption coefficient | 5.08 mm−1 |
F(000) | 1572 |
Crystal size | 0.23 × 0.25 × 0.29 mm3 |
Theta range for data collection | 4.00 to 37.9° |
Index ranges | −27 ≤ h ≤ 30, −29 ≤ k ≤ 15,−9 ≤ l ≤ 17 |
Reflections collected | 6528 |
Independent reflections | 4005(Rint = 0.024) |
Absorption correction | Empirical |
Refinement method | Full-matrix least-squares on F2 |
Data/restraints/parameters | 4005/4/172 |
Goodness-of-fitonF2 | 1.00 |
Final R indices (for 3857 reflections with I > 2σ(I)) | R1 = 0.023, wR2 = 0.055 |
R indices (all data) | R1 = 0.024, wR2 = 0.057 |
Largest diff. peak and hole | 1.37 and −0.55 eÅ−3 |
Absolute structure [5] | Flack parameter = 0.003(3) |
Bi1—Cl2 | 2.5442 (7) | Bi1—N6 | 2.924 (2) | ||
C7—N6 | 1.349 (4) | C7—N8 | 1.359 (4) | ||
C9—N8 | 1.344 (4) | C16—N19 | 1.383 (4) | ||
D—H···A | D—H | H···A | D···A | D—H···A | |
N8—H8···O4 i | 0.86 | 2.13 | 2.858 (3) | 142 | |
N8—H8···Cl2 i | 0.86 | 2.81 | 3.340 (3) | 122 | |
N19—H19A···O5 ii | 0.85 (1) | 2.14 (1) | 2.995 (4) | 177 (5) | |
N19—H19B···Cl2 iii | 0.86 (1) | 2.83 (4) | 3.568 (3) | 146 (5) | |
N19—H19B···Cl2 iv | 0.85(1) | 3.12 (4) | 3.702 (3) | 127 (4) |
Bacterial strains | MIC a/µM | ||
---|---|---|---|
sp | [Bi(sp)3Cl3] | ||
E. coli | ATCC 25922 | >1027 | 241 |
S. aureus | ATCC 25923 | 385 | 90 |
P. aeruginosa | ATCC 24853 | 1027 | 120 |
S. typhimur ium | ATCC 13311 | 96 | 30 |
S. sonnei | ATCC 11060 | 1027 | 241 |
S. dysenteriae | ATCC 13313 | 128 | 30 |
© 2013 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
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Marzano, I.M.; Franco, M.S.; Silva, P.P.; Augusti, R.; Santos, G.C.; Fernandes, N.G.; Bucciarelli-Rodriguez, M.; Chartone-Souza, E.; Pereira-Maia, E.C. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine. Molecules 2013, 18, 1464-1476. https://doi.org/10.3390/molecules18021464
Marzano IM, Franco MS, Silva PP, Augusti R, Santos GC, Fernandes NG, Bucciarelli-Rodriguez M, Chartone-Souza E, Pereira-Maia EC. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine. Molecules. 2013; 18(2):1464-1476. https://doi.org/10.3390/molecules18021464
Chicago/Turabian StyleMarzano, Ivana M., Marina S. Franco, Priscila P. Silva, Rodinei Augusti, Geandson C. Santos, Nelson G. Fernandes, Mônica Bucciarelli-Rodriguez, Edmar Chartone-Souza, and Elene C. Pereira-Maia. 2013. "Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine" Molecules 18, no. 2: 1464-1476. https://doi.org/10.3390/molecules18021464