Effective Hydrogenation of 3-(2”-furyl)- and 3-(2”-thienyl)-1-(2’-hydroxyphenyl)-prop-2-en-1-one in Selected Yeast Cultures
Abstract
:1. Introduction
2. Results and Discussion
Biotransformation
3. Materials and Methods
3.1. Substrate
3.2. Microorganisms
3.3. Analysis
3.4. Gas Chromatography (GC)
3.5. NMR Analysis
3.6. Screening
3.7. Semi-Preparative Scale
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are available from the authors. |
Time [Days] | Strain Number | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
KCh 4 | KCh 71 | KCh 77 | KCh 82 | KCh 120 | KCh 242 | KCh 464 | KCh 909 | ||||||||||
1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | ||
1 | 91 | 23 | 98 | >99 | 92 | 38 | 98 | 59 | 49 | 84 | 0 | 52 | 98 | 98 | 2 | 9 | |
3 | 99 | 33 | >99 | >99 | >99 | 60 | >99 | 84 | >99 | 99 | 0 | 67 | >99 | 99 | 14 | 12 | |
7 | >99 | 49 | >99 | >99 | >99 | 63 | >99 | 97 | >99 | 99 | 17 | 87 | >99 | 98 | 26 | 16 |
Time [h] | Strain Number | |||
---|---|---|---|---|
KCh4 | KCh71 | KCh120 | KCh464 | |
1 | 5 ± 1.1 | 52 ± 4.5 | 2 ± 0.5 | 40 ± 2.1 |
3 | 6 ± 0.1 | 88 ± 1.6 | 2 ± 0.4 | 84 ± 2.9 |
6 | 9 ± 0.5 | >99 ±0.0 | 4 ± 0.9 | 98 ± 0.5 |
12 | 10 ± 0.9 | >99 ± 0.0 | 9 ± 0.5 | 99 ± 0.6 |
Time [h] | Strain Number | |||
---|---|---|---|---|
KCh71 | KCh120 | KCh242 | KCh464 | |
1 | 67 ± 3.9 | 0 ± 0.0 | 1 ± 0.6 | 35 ± 3.6 |
3 | >99 ± 0.0 | 10 ± 1.1 | 5 ± 0.5 | 64 ± 0.9 |
6 | >99 ± 0.0 | 14 ± 1.2 | 9 ± 0.6 | 83 ± 0.6 |
12 | >99 ± 0.0 | 25 ± 3.1 | 12 ± 0.9 | 98 ± 0.3 |
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Łużny, M.; Krzywda, M.; Kozłowska, E.; Kostrzewa-Susłow, E.; Janeczko, T. Effective Hydrogenation of 3-(2”-furyl)- and 3-(2”-thienyl)-1-(2’-hydroxyphenyl)-prop-2-en-1-one in Selected Yeast Cultures. Molecules 2019, 24, 3185. https://doi.org/10.3390/molecules24173185
Łużny M, Krzywda M, Kozłowska E, Kostrzewa-Susłow E, Janeczko T. Effective Hydrogenation of 3-(2”-furyl)- and 3-(2”-thienyl)-1-(2’-hydroxyphenyl)-prop-2-en-1-one in Selected Yeast Cultures. Molecules. 2019; 24(17):3185. https://doi.org/10.3390/molecules24173185
Chicago/Turabian StyleŁużny, Mateusz, Martyna Krzywda, Ewa Kozłowska, Edyta Kostrzewa-Susłow, and Tomasz Janeczko. 2019. "Effective Hydrogenation of 3-(2”-furyl)- and 3-(2”-thienyl)-1-(2’-hydroxyphenyl)-prop-2-en-1-one in Selected Yeast Cultures" Molecules 24, no. 17: 3185. https://doi.org/10.3390/molecules24173185