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Open AccessArticle
Curcumin- Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis
by
Daniel Preda
Daniel Preda 1,
Gabriel Lucian Radu
Gabriel Lucian Radu 2,*,
Emilia-Elena Iorgulescu
Emilia-Elena Iorgulescu 3,
Mihaela-Carmen Cheregi
Mihaela-Carmen Cheregi 3 and
Iulia Gabriela David
Iulia Gabriela David
Iulia Gabriela David earned, from the University of Bucharest, a BS in Chemistry (1989) and a PhD in [...]
Iulia Gabriela David earned, from the University of Bucharest, a BS in Chemistry (1989) and a PhD in Chemistry (1998). She is now Associated Professor of the Department of Analytical Chemistry and Physical Chemistry/Faculty of Chemistry/University of Bucharest. Her work in Analytical Chemistry has resulted in over 100 publications (65 included in WoS), over 90 presentations at different scientific events, 13 courses and 7 awards. She reviewed numerous manuscripts for various chemical journals and guest edited 3 Special Issues. Her research interests include voltammetry, potentiometry, spectrometry, sensors, molecularly imprinted polymers, pharmaceutical analysis.
3,*
1
Doctoral School of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, Gheorghe Polizu Street 1-7, District 1, 011061 Bucharest, Romania
2
National Institute of Biological Sciences, Centre of Bioanalysis, Splaiul Independentei 296, District 6, 060031 Bucharest, Romania
3
Department of Analytical Chemistry and Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Avenue 90-92, District 5, 050663 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Molecules 2024, 29(19), 4630; https://doi.org/10.3390/molecules29194630 (registering DOI)
Submission received: 16 August 2024
/
Revised: 14 September 2024
/
Accepted: 26 September 2024
/
Published: 29 September 2024
Abstract
A new molecularly imprinted polymer (MIP)-based disposable electrochemical sensor for dipyridamole (DIP) determination was obtained. The sensor was rapidly prepared by potentiodynamic electrochemical polymerization on a pencil graphite electrode (PGE) using curcumin (CUR) as a functional monomer and DIP as a template molecule. After the optimization of the conditions (pH, monomer–template ratio, scan rate, number of cyclic voltammetric cycles applied in the electro-polymerization process and extraction time of the template molecule) for MIP formation, DIP voltammetric behavior at the modified electrode (MIP_PGE) was investigated. DIP oxidation took place in a pH-dependent, irreversible mixed diffusion-adsorption controlled process. Differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV) were used to quantify DIP from pharmaceutical and tap water samples. Under optimized conditions (Britton–Robinson buffer at pH = 3.29), the obtained linear ranges were 5.00 × 10−8–1.00 × 10−5 mol/L and 5.00 × 10−9–1.00 × 10−7 mol/L DIP for DPV and AdSDPV, respectively. The limits of detection of the methods were 1.47 × 10−8 mol/L for DPV and 3.96 × 10−9 mol/L DIP for AdSDPV.
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MDPI and ACS Style
Preda, D.; Radu, G.L.; Iorgulescu, E.-E.; Cheregi, M.-C.; David, I.G.
Curcumin- Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis. Molecules 2024, 29, 4630.
https://doi.org/10.3390/molecules29194630
AMA Style
Preda D, Radu GL, Iorgulescu E-E, Cheregi M-C, David IG.
Curcumin- Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis. Molecules. 2024; 29(19):4630.
https://doi.org/10.3390/molecules29194630
Chicago/Turabian Style
Preda, Daniel, Gabriel Lucian Radu, Emilia-Elena Iorgulescu, Mihaela-Carmen Cheregi, and Iulia Gabriela David.
2024. "Curcumin- Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis" Molecules 29, no. 19: 4630.
https://doi.org/10.3390/molecules29194630
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