Hedgehog Signaling Pathway in Ovarian Cancer
Abstract
:1. Introduction
2. Signal Transduction of the Hedgehog Pathway
3. Activation of the Hedgehog Pathway in Human Cancer
4. The Role of Hedgehog Signaling in Cancer Initiation and Progression
5. Small Molecule Modulators of Hedgehog Signaling
5.1. Natural Products and Analogs (Cyclopamine, Its Derivatives, and Others)
5.2. Synthetic Hh Signaling Antagonists
5.3. Hh Signaling Modulators
6. Hedgehog Signaling and Ovarian Cancer
7. Targeting Hedgehog Pathway in Ovarian Cancer
8. Conclusions
- Conflict of InterestThe authors declare no conflict of interest.
References
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Inhibitor | In vitro/in vivo studies | References |
---|---|---|
Cyclopamine | in vitro and in vivo studies | [98–101] |
KAAD cyclopamine | in vitro studies | [102] |
Jervine | in vitro studies | [103] |
Cyc T | in vitro and in vivo studies | [104] |
Cur 61414 | Phase I clinical trial | [88] |
SANT 1,2,3,4 | in vitro studies | [102] |
Compound 5 | in vitro studies | [105] |
Compound Z | in vitro studies | [105] |
GANT-58, -61 | in vitro and in vivo studies | [106] |
IPI 926 | Phase I clinical trial and in vivo studies | [82,94,104,107] |
GDC-0449 (Vismodegib) | Phase I and II clinical trial | [89–93] |
BMS 833923 (XL139) | Phase I clinical trial | [95] |
LDE 225 | Phase I clinical trial | [96] |
Vitamin D3 | in vitro studies | [28] |
Robotnikinin | in vitro studies | [108] |
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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Szkandera, J.; Kiesslich, T.; Haybaeck, J.; Gerger, A.; Pichler, M. Hedgehog Signaling Pathway in Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 1179-1196. https://doi.org/10.3390/ijms14011179
Szkandera J, Kiesslich T, Haybaeck J, Gerger A, Pichler M. Hedgehog Signaling Pathway in Ovarian Cancer. International Journal of Molecular Sciences. 2013; 14(1):1179-1196. https://doi.org/10.3390/ijms14011179
Chicago/Turabian StyleSzkandera, Joanna, Tobias Kiesslich, Johannes Haybaeck, Armin Gerger, and Martin Pichler. 2013. "Hedgehog Signaling Pathway in Ovarian Cancer" International Journal of Molecular Sciences 14, no. 1: 1179-1196. https://doi.org/10.3390/ijms14011179