Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae
Abstract
:1. Introduction
2. HAC1 and Its Translation Control via Ire1p-Mediated Splicing
2.1. Intron-Mediated Translation Control of HAC1 mRNA
2.2. Ire1p-Mediated Splicing of HAC1 mRNA
2.3. Hac1p Triggers UPR and Is Autoregulated
3. Leaky Splicing of HAC1 mRNA in Non-UPR Yeast Cells
4. Leaky Translation of HAC1u
5. Ire1p Domain Structure and Its Splicing Activity
6. How Is Ire1p Activity Regulated in Response to Unfolded/Misfolded Proteins in Yeast?
7. Conservation and Diversification of Ire1p-Mediated UPR Signaling
7.1. Conservation and Diversification of the Ire1p-Hac1p Pathway
7.2. Conservation and Diversity of Ire1p-Mediated Splicing
7.3. Diversity in Translation Control
8. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Gene | SystName | NEE | NEI5 | NEI3 |
---|---|---|---|---|
RPL36B | YPL249C-A | 3603 | 10 | 16 |
RPL18A | YOL120C | 2789 | 10 | 11 |
RPL39 | YJL189W | 7590 | 11 | 40 |
RIM1 | YCR028C-A | 146 | 0 | 1 |
RPL43A | YPR043W | 4083 | 14 | 15 |
RPL40A | YIL148W | 3928 | 5 | 19 |
RPL23B | YER117W | 3192 | 19 | 7 |
RPL2B | YIL018W | 2974 | 4 | 14 |
RPS21B | YJL136C | 4192 | 10 | 14 |
RPL31B | YLR406C | 919 | 4 | 2 |
RPL25 | YOL127W | 6536 | 13 | 22 |
RPL31A | YDL075W | 3032 | 10 | 6 |
RPL6A | YML073C | 3009 | 5 | 10 |
RPS4B | YHR203C | 3411 | 13 | 6 |
RPS21A | YKR057W | 2205 | 5 | 4 |
RPS4A | YJR145C | 4206 | 8 | 10 |
RPL33A | YPL143W | 4880 | 11 | 10 |
SAC6 | YDR129C | 242 | 1 | 0 |
RPS7A | YOR096W | 5093 | 4 | 13 |
HAC1 | YFL031W | 32 | 844 | 704 |
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Xia, X. Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae. Int. J. Mol. Sci. 2019, 20, 2860. https://doi.org/10.3390/ijms20122860
Xia X. Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae. International Journal of Molecular Sciences. 2019; 20(12):2860. https://doi.org/10.3390/ijms20122860
Chicago/Turabian StyleXia, Xuhua. 2019. "Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae" International Journal of Molecular Sciences 20, no. 12: 2860. https://doi.org/10.3390/ijms20122860