Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus
Abstract
:1. Background
2. Frataxin Gene Regulation
3. Deciphering Regulatory Elements in the FXN Locus
3.1. Study of the FXN Locus in the Cell Lines Provided by the ENCODE Consortium
3.2. Study on Tissues and Primary Cultures Provided by the Roadmap Consortium
4. Future Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Chromosome 9 | Chromatin State | |||
---|---|---|---|---|
Nº | Start | End | ||
1 | 71638200 | 71639000 | Enhancer | |
2 | 71642200 | 71643000 | Insulator | |
3 | 71650400 | 71652100 | Promoter | |
4 | 71659400 | 71660200 | Enhancer | |
5 | 71668900 | 71669600 | Insulator | |
6 | 71700500 | 71702000 | Enhancer | |
7 | 71704200 | 71706600 | Enhancer | |
8 | 71710700 | 71713200 | Strong enhancer | |
9 | 71719600 | 71721400 | Enhancer |
H3K4me1 | |||||||
---|---|---|---|---|---|---|---|
Chromosome 9 | Tissues | ||||||
Region | Start | End | Cerebral | Muscular | Others | ||
Up | 1 | 71630400 | 71632000 | 12.14 | 13.50 | 9.67 | |
2 | 71634700 | 71636000 | 5.71 | 3.75 | 10.17 | ||
3 | 71638300 | 71639600 | 8.43 | 5.50 | 10.50 | ||
4 | 71642100 | 71643100 | 13.29 | 9.25 | 12.17 | ||
5 | 71650000 | 71650700 | 19.71 | 20.25 | 14.67 | ||
ORF | I1 | 6 | 71651000 | 71652200 | 20.14 | 17.25 | 16.17 |
7 | 71659300 | 71660200 | 12.14 | 17.25 | 17.83 | ||
I2 | 8 | 71661500 | 71662800 | 10.43 | 4.00 | 4.67 | |
I3 | 9 | 71668400 | 71670400 | 12.29 | 11.50 | 8.67 | |
10 | 71678600 | 71681700 | 9.71 | 8.00 | 9.33 | ||
I4 | 11 | 71683300 | 71686300 | 5.00 | 4.00 | 12.67 | |
12 | 71690700 | 71691900 | 5.29 | 11.50 | 5.33 | ||
13 | 71693000 | 71694500 | 16.71 | 15.50 | 12.67 | ||
14 | 71697600 | 71698700 | 12.50 | 6.50 | 9.67 | ||
15 | 71700300 | 71702400 | 11.86 | 8.50 | 15.50 | ||
16 | 71703700 | 71705900 | 8.71 | 6.50 | 13.00 | ||
17 | 71708600 | 71709200 | 3.86 | 2.50 | 21.33 | ||
18 | 71713500 | 71715400 | 5.57 | 4.00 | 13.17 | ||
Down | 19 | 71718800 | 71721000 | 4.71 | 4.00 | 14.00 | |
20 | 71726500 | 71727400 | 12.00 | 2.25 | 6.67 |
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Fernández-Frías, I.; Pérez-Luz, S.; Díaz-Nido, J. Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus. Int. J. Mol. Sci. 2020, 21, 3410. https://doi.org/10.3390/ijms21103410
Fernández-Frías I, Pérez-Luz S, Díaz-Nido J. Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus. International Journal of Molecular Sciences. 2020; 21(10):3410. https://doi.org/10.3390/ijms21103410
Chicago/Turabian StyleFernández-Frías, Iván, Sara Pérez-Luz, and Javier Díaz-Nido. 2020. "Analysis of Putative Epigenetic Regulatory Elements in the FXN Genomic Locus" International Journal of Molecular Sciences 21, no. 10: 3410. https://doi.org/10.3390/ijms21103410