Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants
Abstract
:1. Introduction
2. Bacterial Biofilm in Implant-Related Infections
3. Bacteria in Orthopaedic Implant-Related Infections
4. Novel Implant Surface Technology
5. Passive Surface Modification
6. Active Surface Modification
7. Local Carriers and Coatings
8. Biofilm Eradication Strategies
9. Conclusions
Author Contributions
Funding
Informed Consent Statement
Conflicts of Interest
References
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Prevention of Orthopaedic Implant-Related Infection |
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Optimisation of Preoperative Medical Conditions |
Systemic prophylaxis in a 24-h regimen |
Good clinical and logistic practice in operating rooms |
Optimal air conditions |
Shorter surgical interventions |
Anti-infective coatings and implants |
Optimal postoperative treatment |
Summary of Recent Publications on Different Strategies to Reduce Biofilm Formation on Orthopaedic Implants. |
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Local administration of nanotube-based antibiotics could be a good future strategy to combat infections associated with orthopaedic implants. |
Combination of silver-containing hydroxyapatite coating and vancomycin reduces the formation of MRSA biofilms and, therefore, could be useful to prevent and treat periprosthetic joint infections. |
Peptide-coated surface with micropatterned topography can reduce adhesion and subsequent biofilm formation on orthopedic implants. |
An effective strategy to eliminate biofilms is to use phages or lysins in combination with antibiotics. |
Bacteriophage-encapsulating hydrogels may be useful for treating local bone infections. |
Implants with uniform surfaces and minimal imperfections can reduce the ability of bacteria to adhere to them. |
Sponge-associated Enterobacter 84.3 is a source of substances capable of eradicating staphylococcal biofilm. |
The lipopeptide produced by Bacillus subtilis ATCC 19,659 may be of great interest in the future to avoid infections related to orthopedic implants. |
MRSA = Methicillin-resistant Staphylococcus Aureus |
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Rodríguez-Merchán, E.C.; Davidson, D.J.; Liddle, A.D. Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants. Int. J. Mol. Sci. 2021, 22, 10243. https://doi.org/10.3390/ijms221910243
Rodríguez-Merchán EC, Davidson DJ, Liddle AD. Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants. International Journal of Molecular Sciences. 2021; 22(19):10243. https://doi.org/10.3390/ijms221910243
Chicago/Turabian StyleRodríguez-Merchán, Emérito Carlos, Donald J. Davidson, and Alexander D. Liddle. 2021. "Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants" International Journal of Molecular Sciences 22, no. 19: 10243. https://doi.org/10.3390/ijms221910243