Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues
Abstract
:1. Introduction
2. Results
2.1. hApoD Exits the Central Nervous System and Reaches Peripheral Tissues
2.2. hApoD Accumulates in Specific Tissues
2.3. hApoD Transcytoses through bEnd.3 Brain Endothelial Barrier Cells
2.4. Cyclophilin A Competition Does Not Reduce hApoD Internalization in Brain Endothelial Barrier Cells
2.5. Relationship between BSG Glycosylation and hApoD Accumulation
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Protein Radiolabelling
4.3. Intracerebroventricular and Intravascular Injections
4.4. Tissue and Fluid Sample Preparation
4.5. Cell Culture
4.6. Immunofluorescence
4.7. Immunoblotting
4.8. Statistics
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Desmarais, F.; Hervé, V.; Bergeron, K.F.; Ravaut, G.; Perrotte, M.; Fyfe-Desmarais, G.; Rassart, E.; Ramassamy, C.; Mounier, C. Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. Int. J. Mol. Sci. 2021, 22, 4118. https://doi.org/10.3390/ijms22084118
Desmarais F, Hervé V, Bergeron KF, Ravaut G, Perrotte M, Fyfe-Desmarais G, Rassart E, Ramassamy C, Mounier C. Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. International Journal of Molecular Sciences. 2021; 22(8):4118. https://doi.org/10.3390/ijms22084118
Chicago/Turabian StyleDesmarais, Frederik, Vincent Hervé, Karl F. Bergeron, Gaétan Ravaut, Morgane Perrotte, Guillaume Fyfe-Desmarais, Eric Rassart, Charles Ramassamy, and Catherine Mounier. 2021. "Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues" International Journal of Molecular Sciences 22, no. 8: 4118. https://doi.org/10.3390/ijms22084118