Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring
Abstract
:1. Introduction
2. Results
2.1. Body Weight and Morphometrical Bone Parameters
2.2. Mechanical Bone Parameters
2.3. Hormonal Analysis
2.4. Protein Expression
2.5. Trabecular Bone Morphology
3. Discussion
4. Materials and Methods
4.1. Fumonisins Preparation and Quantification
4.2. Animals and Experimental Design
4.3. Mechanical Testing
4.4. Trabecular Bone Morphology
4.5. Western Blot
4.6. Hormonal Analysis
4.7. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Tomaszewska, E.; Rudyk, H.; Muszyński, S.; Hułas-Stasiak, M.; Leszczyński, N.; Mielnik-Błaszczak, M.; Donaldson, J.; Dobrowolski, P. Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring. Int. J. Mol. Sci. 2023, 24, 8743. https://doi.org/10.3390/ijms24108743
Tomaszewska E, Rudyk H, Muszyński S, Hułas-Stasiak M, Leszczyński N, Mielnik-Błaszczak M, Donaldson J, Dobrowolski P. Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring. International Journal of Molecular Sciences. 2023; 24(10):8743. https://doi.org/10.3390/ijms24108743
Chicago/Turabian StyleTomaszewska, Ewa, Halyna Rudyk, Siemowit Muszyński, Monika Hułas-Stasiak, Norbert Leszczyński, Maria Mielnik-Błaszczak, Janine Donaldson, and Piotr Dobrowolski. 2023. "Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring" International Journal of Molecular Sciences 24, no. 10: 8743. https://doi.org/10.3390/ijms24108743