A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation
Abstract
:1. Introduction
2. SIRT3 and Longevity
3. Subcellular Localization
4. Indirect CNS Actions of SIRT3 through Peripheral Tissues
4.1. Liver
4.2. Skeletal Muscle
4.3. Heart
4.4. Vascular Endothelial Cells
4.5. Brain Microvascular Endothelial Cells
5. Pathways of SIRT3 Action
5.1. SIRT3 and Mitochondrial Bioenergetics
5.2. Regulation of Brain Metabolism by SIRT3
5.3. Anti-Inflammatory Effects of SIRT3
5.4. Antioxidant Effects of SIRT3
5.5. Mitophagy and Autophagy
6. SIRT3 Downregulation in Disease Conditions
6.1. Metabolic Syndrome and Diabetes
6.2. Role of SIRT3 Downregulation in Neurodegenerative Diseases
6.2.1. Alzheimer’s Disease
6.2.2. Parkinson’s Disease
6.2.3. Huntington Disease
6.2.4. Amyotrophic Lateral Sclerosis
6.2.5. Ischemic Stroke and Other Brain Injury Models
7. Translational Significance of SIRT3 Activation
7.1. SIRT3 Activation by Lifestyle-Based Intervention
7.2. NAD+ Precursors
7.3. Naturally Occurring SIRT3 Activators
7.3.1. Honokiol
7.3.2. Resveratrol
7.3.3. Other Naturally Occurring SIRT3 Activators
Activators of Sirt3 | Source | Disease Condition/Cell Type | References |
---|---|---|---|
Nicotinamide riboside chloride | Vitamin B3 derived | Hearing loss/ear Liver regeneration/ | Brown et al. [158] |
AD | Gong et al. [159] | ||
Healthy Adults | Martens et al. [160] | ||
Healthy Overweight Adults | Conze et al. [161] | ||
Honokiol | Magnolia | Glioma | Wang et al. [163] |
AD/neurons | Li et al. [165] | ||
Oxygen-Glucose Deprivation/Reperfusion-Induced Neuronal injuries/Neurons | Wan et al. [166] | ||
Memory loss/brain | Ye et al. [167] | ||
Liver damage/AML12 hepatocytes | Liu et al. [168] | ||
Liver damage/liver/AML12 hepatocytes | Liu et al. [169] | ||
Cardiac hypertrophy/primary cardiomyocytes | Pillai et al. [170] | ||
Radiation-induced brain injury | Liao et al. [171] | ||
Resveratrol | Grapes, apples, peanuts, blueberries | Diabetic rat heart/heart/H9C2 cell line | Bagul et al. [172] |
Pulmonary arterialhypertension/cardiomyocytes | Bernal-Ramirez et al. [173] | ||
Cardiovascular/HUVECs | Zhou et al. [174] | ||
Myocardial Ischemia/Reperfusion Injury/ primary Rat cardiomyocyte | Zheng et al. [175] | ||
ER stress/HT22 cells-neuronal cell line | Yan et al. [176] | ||
ε-Viniferin | Grapevines | Huntington disease/Primary cortical neurons | Fu et al. [137] |
Polydatin | Grapes, peanuts, mulberry | Vascular endothelial/HUVECs Endothelial cells | Wu et al. [177] |
Curcumin | Turmeric | Dementia/neurons | Liu et al. [149] |
Salidroside | Rhodiola plants | Myocardial dysfunction/heart | Li et al. [180] |
Phloretin | Apple and apricot | Cardiovascular/mouse aortas/HUVECs | Han et al. [181] |
Acacetin | Safflower, snow lotus | Diabetic/aorta tissue/HUVECs | Han et al. [182] |
Spinacetin | Spinach | Cardiotoxicity/ heart/H9C2 cell line | Liu et al. [183] |
Theacrine | Camellia kucha | Parkinson’s disease/H-SY5Y cells | Duan et al. [184] |
Trilobatin | Crabapple | Alzheimer’s disease/hippocampus /BV2 cells | Gao et al. [185] |
Injury in neurons/neuronal PC12 | |||
Sesamin and sesamol | Fagara and Sesame oil | Neurodegenerative disorders/neuronal cells | Ruankham et al. [186] |
Dihydromyricetin | Chinese vine tea plant | Memory impairment/ hippocampus/HT 22 cells | Liu et al. [187] |
Elabela | Hormonal peptide | Diabetic | Li et al. [188] |
Metformin | Galegine | Hypoxia/reoxygenation (H/R) injury/rat cardiomyocyte | Du et al. [189] |
Cardiovascular and liver diseases/heart and liver | Gao et al. [190] |
8. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Tyagi, A.; Pugazhenthi, S. A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation. Int. J. Mol. Sci. 2023, 24, 1615. https://doi.org/10.3390/ijms24021615
Tyagi A, Pugazhenthi S. A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation. International Journal of Molecular Sciences. 2023; 24(2):1615. https://doi.org/10.3390/ijms24021615
Chicago/Turabian StyleTyagi, Alpna, and Subbiah Pugazhenthi. 2023. "A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation" International Journal of Molecular Sciences 24, no. 2: 1615. https://doi.org/10.3390/ijms24021615