Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus
Abstract
:1. Introduction
2. Results
2.1. Chronic Administration of ONX-0914 Modulates LTP in the Hippocampus Following Tetanic Stimulation, but Not Short Theta-Burst Stimulation
2.2. Chronic Administration of ONX-0914 Results in Altered Expression of Glutamate Signaling-Related Genes
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Administration of ONX-0914
4.3. Preparation and Treatment of Hippocampal Slices
4.4. Electrophysiology
4.5. RNA Extraction and RNA-Seq
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Maltsev, A.; Funikov, S.; Rezvykh, A.; Teterina, E.; Nebogatikov, V.; Burov, A.; Bal, N.; Ustyugov, A.; Karpov, V.; Morozov, A. Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus. Int. J. Mol. Sci. 2023, 24, 8172. https://doi.org/10.3390/ijms24098172
Maltsev A, Funikov S, Rezvykh A, Teterina E, Nebogatikov V, Burov A, Bal N, Ustyugov A, Karpov V, Morozov A. Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus. International Journal of Molecular Sciences. 2023; 24(9):8172. https://doi.org/10.3390/ijms24098172
Chicago/Turabian StyleMaltsev, Alexander, Sergei Funikov, Alexander Rezvykh, Ekaterina Teterina, Vladimir Nebogatikov, Alexander Burov, Natalia Bal, Aleksey Ustyugov, Vadim Karpov, and Alexey Morozov. 2023. "Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus" International Journal of Molecular Sciences 24, no. 9: 8172. https://doi.org/10.3390/ijms24098172