Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

Min, Ki Ha; Kim, Dong Hyun; Youn, Sol; Pack, Seung Pil

doi:10.3390/ijms25042023

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Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

by

Ki Ha Min

¹,

Dong Hyun Kim

²,

Sol Youn

² and

Seung Pil Pack

^2,*

¹

Institution of Industrial Technology, Korea University, Sejong 30019, Republic of Korea

²

Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2024, 25(4), 2023; https://doi.org/10.3390/ijms25042023

Submission received: 3 January 2024 / Revised: 28 January 2024 / Accepted: 5 February 2024 / Published: 7 February 2024

(This article belongs to the Special Issue Biological and Molecular Research of Novel Biomimetic Materials 2023)

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Abstract

Diatom biosilica is an important natural source of porous silica, with three-dimensional ordered and nanopatterned structures referred to as frustules. The unique features of diatom frustules, such as their high specific surface area, thermal stability, biocompatibility, and adaptable surface chemistry, render diatoms valuable materials for high value-added applications. These attributes make diatoms an exceptional cost-effective raw material for industrial use. The functionalization of diatom biosilica surface improves its biophysical properties and increases the potential applications. This review focuses on the potential uses of diatom biosilica including traditional approaches and recent progress in biomedical applications. Not only well-studied drug delivery systems but also promising uses on bone regeneration and wound healing are covered. Furthermore, considerable aspects and possible future directions for the use of diatom biosilica materials are proposed to develop biomedical applications and merit further exploration.

Keywords: diatom; diatomite; biosilica; bone regeneration; wound healing; drug delivery

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MDPI and ACS Style

Min, K.H.; Kim, D.H.; Youn, S.; Pack, S.P. Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review. Int. J. Mol. Sci. 2024, 25, 2023. https://doi.org/10.3390/ijms25042023

AMA Style

Min KH, Kim DH, Youn S, Pack SP. Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review. International Journal of Molecular Sciences. 2024; 25(4):2023. https://doi.org/10.3390/ijms25042023

Chicago/Turabian Style

Min, Ki Ha, Dong Hyun Kim, Sol Youn, and Seung Pil Pack. 2024. "Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review" International Journal of Molecular Sciences 25, no. 4: 2023. https://doi.org/10.3390/ijms25042023

APA Style

Min, K. H., Kim, D. H., Youn, S., & Pack, S. P. (2024). Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review. International Journal of Molecular Sciences, 25(4), 2023. https://doi.org/10.3390/ijms25042023

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Biomimetic Diatom Biosilica and Its Potential for Biomedical Applications and Prospects: A Review

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