Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus influenzae Meningitis in a Newborn
Abstract
:1. Introduction
2. Setting and Case Report
Case Report
3. Materials and Methods
Assessment of Sample
4. Results
4.1. Laboratory and Clinical Epidemiological Characterization
4.2. Metagenomic Analysis of the CSF Samples
4.3. Phylogenetic Analysis
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Collection Date | 28 May | 29 May | 22 June | 6 June | 8 June | 12 June | 16 June | 18 June | 24 June | |
---|---|---|---|---|---|---|---|---|---|---|
Collect CSF | CSF1 Admission | CSF2 | CSF3 | CSF4 Case | CSF5 | CSF6 | CSF7 | CSF8 | CSF9 | Reference |
Cells (mm³) | 217 | 43 | 395 | 213 | 80 | 170 | 72 | 47 | 41 | Until 4 cells |
Red cells (mm³) | 1 | 906 | 221 | 225 | 118 | 1 | 2 | 0 | 1360 | 0 Red Cells |
Lymphocytes (%) | 18 | 56 | 5 | 19 | 33 | 28 | 47 | 28 | 35 | 70–80 |
Monocytes (%) | 10 | 22 | 31 | 47 | 40 | 15 | 18 | 12 | 7 | 60–80 |
Plasmocytes (%) | 2 | 1 | 0 | 3 | 7 | 37 | 32 | 58 | 51 | N/A |
Neutrophils (%) | 67 | 17 | 52 | 21 | 14 | 17 | 1 | 2 | 5 | N/A |
Eosinophils (%) | 2 | * | 2 | 3 | 1 | 2 | 1 | * | 1 | N/A |
Basophils (%) | 1 | 3 | 0 | 5 | 4 | 1 | 1 | * | 1 | N/A |
Macrophages (%) | * | 1 | 10 | 1 | 1 | * | 1 | * | * | N/A |
Total protein (mg/dL) | 247 | 188 | 384 | 301 | 214 | 114 | 273 | 228 | 93 | Lumbar–until 40 |
Glucose (mg/dL) | 40 | 27 | 21 | 21 | 31 | 30 | 31 | 34 | 55 | 50–70 |
Lactate (mg/dL) | 36.9 | 31.5 | 36.9 | 36 | 28.8 | 22.5 | 29.7 | 25.2 | 22.5 | 10.0–22.0 |
Microbiological tests | Negative | Negative | Negative | Negative | Negative | Negative | Negative | Negative | Negative | N/A |
PCR tests other virusesa | * | * | * | Negative | * | * | * | * | * | N/A |
qPCR Parvovirus B19 | * | * | * | Positive | * | * | * | * | * | N/A |
Date Blood Collection | 28 May | 29 May | 30 May | 3 June | 5 June | |
---|---|---|---|---|---|---|
Admission | Case | Reference Value | ||||
Erythrocytes (×106/L) | 3.99 | 3.88 | 3.65 | 3.38 | 3.56 | 3.2–4.9 |
Hemoglobin (g/dL) | 11 | 10.8 | 10.3 | 9.6 | 9.9 | 10.3–13.7 |
Hematocrit (%) | 32.2 | 32.1 | 30.4 | 28.1 | 29.7 | 34–48 |
MCV (fL) | 80.7 | 82.7 | 83.3 | 83.1 | 83.4 | 80–114 |
HCM (pg) | 27.6 | 27.8 | 28.2 | 28.4 | 27.8 | 24–34 |
MCHC (g/dL) | 34.2 | 33.6 | 33.9 | 34.2 | 33.3 | 28–32 |
RDW (%) | 17.0 | 17.4 | 17.3 | 16.9 | 16.7 | 11.6–14.8 |
Leukocytes (×103/mm3) | 22.33 | * | 13.83 | 16.84 | 13.84 | 6–18 |
Rod neutrophils (%) | 8 | 4 | 2 | * | * | 3.8–4.4 |
Segmented neutrophils (%) | 70 | 65 | 75 | 38 | 46 | 28–30 |
Lymphocytes (%) | 16 | 17 | 10 | 32 | * | 57–61 |
Monocytes (%) | 6 | 5 | 5 | 12 | 4 | 4.8–5.9 |
Platelets (K/L) | 487 | 466 | 108 | 814 | 1212 | 150–450 |
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Ferreira, N.E.; da Costa, A.C.; Kallas, E.G.; Silveira, C.G.T.; de Oliveira, A.C.S.; Honorato, L.; Paião, H.G.O.; Lima, S.H.; de M. Vasconcelos, D.; Côrtes, M.F.; et al. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus influenzae Meningitis in a Newborn. Curr. Issues Mol. Biol. 2023, 45, 6958-6966. https://doi.org/10.3390/cimb45090439
Ferreira NE, da Costa AC, Kallas EG, Silveira CGT, de Oliveira ACS, Honorato L, Paião HGO, Lima SH, de M. Vasconcelos D, Côrtes MF, et al. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus influenzae Meningitis in a Newborn. Current Issues in Molecular Biology. 2023; 45(9):6958-6966. https://doi.org/10.3390/cimb45090439
Chicago/Turabian StyleFerreira, Noely Evangelista, Antonio C. da Costa, Esper G. Kallas, Cassia G. T. Silveira, Ana Carolina S. de Oliveira, Layla Honorato, Heuder G. O. Paião, Silvia H. Lima, Dewton de M. Vasconcelos, Marina F. Côrtes, and et al. 2023. "Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus influenzae Meningitis in a Newborn" Current Issues in Molecular Biology 45, no. 9: 6958-6966. https://doi.org/10.3390/cimb45090439